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The objective of this paper is to evaluate the rate of detection of chromosomal abnormalities through the non-invasive prenatal test (NIPT) and its contribution to reducing the number of invasive tests. We conducted a prospective study on a batch of 3,000 single-pregnancy pregnancies highlighted in the first trimester. The patients were divided into two study groups, the first group, which we will call the TPNI (Non-Invasive Prenatal Test) group. First trimester screening was performed by non-invasive prenatal test at 10 weeks, and ultrasound between 11-13 +/- 6 days according to the criteria of the Fetal Medicine Foundation (FMF. London, UK). The sensitivity, specificity and accuracy of the two screening methods are almost similar, using NITP screening we obtain a rate of approximately 20% lower false-positive results, and we also perform a smaller number of invasive tests.

IUGR remains an important health problem in developing countries around the world, being one of the major obstetrical syndromes associated with placental defects, but also one of the topical issues of neonatology, and in particular the association between IUGR and prematurity under 32 weeks of gestation. Neonatal morbidity and mortality remain significant and has an important economic impact. The need for more stringent diagnostic criteria remains a problem. The study proposes to follow the time of extraction of a premature pregnancy IUGR with gestation age �32 weeks, taking into account the centralization of bloodflow as well as IH (hypoxic index) during observation, following the immediate consequences on this new category - as well as their prognosis depending on the associated pathology using cerebral serial Doppler ultrasounds and near-infrared spectroscopy (NIRS).

Acetylsalicylic acid, classified under the non-steroidal anti-inflammatory drugs (NSAIDS) has well known anti-inflammatory, anti-pyretic properties, anti-platelet aggregation effect and analgesic properties. Pre-eclampsia (PE) is a pathology of pregnancy characterized by the onset of hypertension and often accompanied by the lost of significant amount of protein in the urine. In pregnant women with risk of preeclampsia, low doses of aspirin have been shown to have a beneficial effect on the incidence of this disorder. Using a retrospective design, we screened for preeclampsia all pregnancies followed in a time interval of 2 years. We have observed that in preeclampsia high risk patients based on the screening done between 11 to 13 weeks and 6 days, the administration of low doses of acetylsalicylic acid reduced the burden of disease. Identifying the pregnancy having high risk for preeclampsia in the first trimester helps us in decision making for initiating prophylactic treatment with Aspirin.