1. Response inhibition alterations in migraine: Evidence from event-related potentials and evoked oscillations
- Author
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Zhao Dong, Yansong Li, Ignacio Obeso, Rongfei Wang, Guoliang Chen, Zhao Dengfa, and Shengyuan Yu
- Subjects
Delta oscillation ,Aura ,Migraine Disorders ,lcsh:Medicine ,Stop signal ,03 medical and health sciences ,0302 clinical medicine ,Event-related potential ,Parietal Lobe ,Motor system ,medicine ,Reaction Time ,Humans ,Ictal ,Cortical disexcitability ,Evoked Potentials ,Migraine ,030304 developmental biology ,0303 health sciences ,business.industry ,lcsh:R ,N2 ,Cognition ,P3 ,Neural Inhibition ,General Medicine ,ERPs ,Theta oscillation ,medicine.disease ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Scalp ,Response inhibition ,Female ,Neurology (clinical) ,business ,Neuroscience ,030217 neurology & neurosurgery ,Research Article - Abstract
Background Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs. Methods Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition. Results Behaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs. Conclusions Consistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.
- Published
- 2020