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Cisplatin is a therapeutic drug widely used to treat various solid tumors. Nephrotoxicity is a well-known side effect in patients treated with cisplatin. Falcarindiol (FAD), natural polyacetylene compound greatly found in Apiaceae family, has anti-cancer, -bacterial, -inflammatory and -oxidant activity which is utilized in the present study. Thirty male C57BL/6 mice were randomly divided into five groups of six each; sham, cisplatin (15 mg/kg), cisplatin + FAD (50 and 100 mg/kg/day), and FAD (100 mg/kg/day). Cisplatin administration elevated the concentrations of BUN and creatinine, as well as kidney histopathologic damage. On the other hand, FAD treatment attenuated cisplatin-induced injury, and also down-regulated mRNA levels of TNF-α and IL-1β together with protein expression of p-NF-kB p65. Moreover, FAD induced the protein expression of p-AMPK and nuclear Nrf2 accompanied by its respective target genes such as NQO-1 and HO-1 in a dose-dependent manner. In conclusion, the findings collectively characterize FAD as a drug candidate to treat cisplatin-induced nephrotoxicity thorough down-regulation of NF-kB signaling pathway in mice

This study aimed to investigate the relatively explicit (errorful) or implicit (errorless) conditions on the learning the relative timing was a motor task. Healthy participants (N = 38, Mage = 22.6 years, SDage = 3.2 years) were randomly assigned to one of three groups (control, errorful, errorless). We conducted the study in four phases: (1) Pretest; (2) Acquisition (group specific); (3) Retention at 10-minutes and 24-hours post-acquistion; (4) Transfer at 10-minutes and 24-hours post-acquisition. Each phase consisted of 10 trials, except for Acquisition, which consisted of 45 trials. The transfer tests and also the high correlation between scores the total MSRS scores with errorful and control schedules. participants were tested, in a novel total movement, timing creations and relative timing structure (1300 MS, 325 MS for each segment, respectively). In both the retention and transfer tests, the errorless group in the relative timing ( RMSE) performed more accurately than other groups ( p ≤ 0.05). These results suggest that implicit learning in the form of errorless acquisition results is a smoother and more accurate motor performance for the retention and transfer tests. The results support previous findings that display an errorless learning paradigm, effectively minimize skill degradation under pressure conditions that are further consistent with the implicit learning and reinvestment theories.

This study was designed to compare the mental health and quality of life of athlete and non-athlete adolescents during the COVID-19 pandemic. The study statistical population included all adolescents aged 14 to 18 years living in Mazandaran province, out of which, 2897 adolescents were randomly selected. We performed an online survey among adolescents in Mazandaran province using GAD-7, PHQ-9, PFABS, and PEDSQL questionnaires. According to the results, athlete adolescents showed lower levels of anxiety and depression and higher quality of life compared to non-athlete adolescents. Moreover, the findings indicated that as the number of practice sessions increases throughout the week, the scores of physical activity and quality of life of athlete adolescents increase and their overall depression and anxiety scores decrease; however, the scores of generalized anxiety, depression, and quality of life among adolescent athletes with different training sessions in a week seem to be equal with no significant difference between them. The present results confirm the positive effect of physical activity on the mental health and quality of life related to the health of student adolescents.