1. Association between cancer risk and HLA genotype can be explained by anti-tumor immunity
- Author
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Katalin Pántya, Orsolya Lorincz, Levente Molnár, Eszter Somogyi, Péter Páles, Zsolt Csiszovszki, József Tóth, István Miklós, and Toke Eniko R
- Subjects
Hla genotype ,Text mining ,Antitumor immunity ,business.industry ,Association (object-oriented programming) ,Immunology ,Medicine ,Cancer risk ,business - Abstract
Over recent decades, efforts to explain the heritability of developing cancer have focused on identifying high-risk genes and common genetic variants. However, no studies considered genetic factors regulating tumor-specific immune responses. By developing a novel human leukocyte antigen (HLA) score, determined by autologous HLA allele-binding epitopes of tumor-specific antigens, we showed that individuals with HLA allele sets supporting broader tumor-specific T cell responses have lower risk of developing melanoma. The risk ratio between the highest risk and most protected groups was 5.69 comparing the top and bottom 20% of the HLA score distribution (p
- Published
- 2021
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