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Background Neoadjuvant chemotherapy has been widely applied in operable breast cancer patients. This study aim to identify the predictive factors of overall survival(OS) and recurrence free survival (RFS) in breast cancer patients who received NAC from a single Chinese institution . Patients and Methods There were 646 patients recruited in this study. All the patients were treated at department of Surgical Oncology, Sir Run Run Shaw Hospital between February 25, 1999 and August 22, 2018. The relevant clinicopathological and follow-up data were collected retrospectively. RFS and OS were assessed using the Kaplan-Meier method. Multivariate Cox proportional hazards model was also employed.Multi-variate logistic regression model was simulated to predict pathologic complete response (pCR) . Results In total, 126 patients (19.5%) achieved pCR during NAC. The 5-year OS was 92.6% and 75.3% in patients with and without pCR, respectively (P25 (HR, 2.363; P=0.044), lymph node involvement after NAC(HR,3.639; P

Background: Lymphopenia was often observed during follow-up for cancer patients, this study aimed to evaluate the prognostic value of prolonged lymphopenia for breast cancer patients. Methods: This was a retrospective cohort analysis of 296 patients with clinical stage I-III operable breast cancer, who had received chemotherapy and/or radiotherapy. Absolute lymphocyte count lower than 1.1×10^3/ul was defined as lymphopenia. Lymphopenia around the 6th month after chemo-radiotherapy was defined as cohort L, while normal Absolute lymphocyte count was defined as cohort N. Predictors of lymphopenia were assessed using univariate and multivariate logistic regression analyses. Kaplan–Meier and Cox regression analyses were used to evaluate the relationship between the two cohorts. Results: The baseline characteristics analysis: comparing to cohort N, cohort L had more Stage III(47.4% vs. 25.5%) and less Stage I cancer(12.3% vs. 20.1%)(p=0.005), more patients experienced combined chemotherapy regimen(86.0% vs. 69.5%, p=0.012), more patients experienced radiotherapy(78.9% vs. 64.9%, p=0.041), and less patients experienced endocrine therapy(54.4% vs. 68.2%, p=0.049). Multivariate logistic regression analysis revealed two negative independent factors associated with DFS: pTNM staging (stage II vs. I: HR=5.346, 95% CI: 2.286-12.504, pConclusion: Persistent lymphopenia after chemotherapy and/or radiotherapy was an independent predictor for breast cancer relapse and unfavorable survival.

Background: To evaluate the guiding effect of digital image based on cone-beam computed tomographic in improving the quality of single oval root canal preparation.Methods: A premolar was selected by CBCT and a 3D-printed root canal model was made. Twenty postgraduates from the Department of Stomatology of Shanghai Ninth People's Hospital were selected to perform root canal preparation on 3D printed oval root canal model teeth. They were randomly assigned to two groups(n=10) according to the guiding method received: CBCT original image (control group) and CBCT-based digital image (experimental group). CBCT scans were performed on the models before and after the guidance. The changes in root canal cleanliness, residual minimum thickness, transportation and over-preparation amount were analyzed.Results: The experimental group caused significantly more increased amount of cleanliness compared to control group(P0.05)： 0.0154mm±0.2110mm in the control group and 0.0362±0.0444mm in the experimental group. In the control group, the transportation after second preparation was generally increased (increased 0.0084mm on average). In the experimental group, the transportation was generally reduced after second preparation (reduced 0.0081mm on average). But there was no significant difference in the transportation change between the two groups (P>0.05). After the second preparation, there was no significant difference in the amount of increased over-preparation between the two groups（P＞0.05）: 1.7029%±3.6622% in the control group and 3.5144%±4.8075% in the experimental group.Conclusions: Compared with traditional CBCT image guidance, the digital image method can significantly improve the cleaning effect of the oval root canal preparation. It didn’t result in more over-preparation and the amount of residual wall thickness was ensured. At the same time, it has a certain effect on reducing transportation after the guidance.