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To address the problem that the traditional correlation metric defaults the 0 terms in the adjacency matrix of lncRNA-disease to irrelevant, ignoring the fact that it is only not validated now but maybe validated as relevant in the future, we propose a correlation calculation method that incorporates potential correlation properties, which is verified by comparative experiments to have better performance than the traditional method in the model; meanwhile, with the idea of nearest neighbor, we design the matrix completion model (DMWNN) to reassign values to the 0-terms in the adjacency matrix. The correlation is used instead of the traditional Euclidean distance to screen more valuable neighbors; combined with the linear decay strategy of distance weights, the interference of low correlation data is reduced, and thus the accuracy of reassignment is improved. The AUC value reached 0.9480 in the five-fold cross-validation experiment and 0.9603 in the leave-one-out cross-validation experiment, and the experimental results showed that the DMWNN model can effectively explore the potential association between lncRNA and disease and has strong predictive performance.

The myodural bridge (MDB) is a dense connective tissue structure between the suboccipital musculature and the spinal dura mater (SDM). However, few reports on the development and maturation of the human MDB. 30 head and neck specimens from human fetuses (F) from 12–40 weeks (W) were made into histological sections. The F12W sections evidenced that the SDM dominated by fibroblasts, attached to the posterior atlantoaxial membrane (PAAM) which completely sealed the atlantoaxial space. In the F13W stage, myofibrils of the suboccipital muscle fibers increased significantly in number. At the F14W stage, a gap was observed at the caudal end of the PAAM. Numerous myodural bridge-like structures were observed blending into the SDM through the gap. At the F15W stage, the MDB fibers originated between the posterior arch of atlas (C1) and the obliquus capitis inferior muscle, and extended forward and downward into the spinal canal through the atlantoaxial gap. Starting at the F21W stage, the MDB fibers were observed to pass through the atlantoaxial interspace and radially attach to the SDM. The present study adds to the knowledge base of developmental morphology research of the human embryonic MDB and provides a developmental morphological basis for its potential functionality.

Glioma is the most common and fatal primary brain tumor in humans. Myosin binding protein H (MYBPH), which was first identified as an important myofibrillar constituent of vertebrate skeletal and cardiac muscles, reduces cell motility and metastasis. However, its role in gliomas remains unclear. We evaluated the expression of MYBPH in glioma using Gene Expression Profiling Interactive Analysis (http://gepia.cancer-pku.cn/) and Chinese Glioma Genome Atlas (https://www.cgga.org.cn/). The results showed that MYBPH was highly expressed in glioma tissues. Moreover, MYBPH expression was significantly associated with high tumor aggressiveness and poor outcomes in glioma patients. Mechanistically, the results suggested that MYBPH might promote tumor progression by improving tumor invasion and migration. Our results establish MYBPH as an important prognostic biomarker that could be considered a potential epigenetic and immunotherapeutic target for treatment. We showed that MYBPH is a novel biomarker that is variably expressed in glioblastoma (GBM). The association of high MYBPH expression with poor prognosis in newly diagnosed GBM patients and increased expression in recurrent GBM is indicative of its role in tumor aggressiveness.