1. The Association of Baseline N-terminal Pro-B-type Natriuretic Peptide With Short and Long-term Prognosis Following Percutaneous Coronary Intervention in Non-ST Segment Elevation Acute Coronary Syndrome With Multivessel Coronary Artery Disease: a Retrospective Cohort Study
- Author
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Jiyan Chen, Wei Chen, Ning Tan, Wen-Fei He, Hua-Lin Fan, Zhi-Kai Liu, Chong-Yang Duan, Peng-Cheng He, Li-Huan Zeng, Jun Li, Wei Guo, Zhi-Qiang Guo, Lei Jiang, Peng-Yuan Chen, Yuanhui Liu, Xue-Biao Wei, Yi-Yue Chen, and Wen-Sheng Li
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary artery disease ,0302 clinical medicine ,Risk Factors ,Cause of Death ,Natriuretic Peptide, Brain ,Natriuretic peptide ,Medicine ,ST segment ,Non-ST segment elevation acute coronary syndrome ,030212 general & internal medicine ,Hospital Mortality ,Non-ST Elevated Myocardial Infarction ,Aged, 80 and over ,N-terminal pro-B-type natriuretic peptide ,Mortality rate ,Middle Aged ,Treatment Outcome ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Research Article ,Multivessel coronary artery disease ,Adult ,medicine.medical_specialty ,Acute coronary syndrome ,medicine.drug_class ,Risk Assessment ,03 medical and health sciences ,Percutaneous Coronary Intervention ,Predictive Value of Tests ,Internal medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,cardiovascular diseases ,Aged ,Retrospective Studies ,business.industry ,Percutaneous coronary intervention ,Retrospective cohort study ,medicine.disease ,Peptide Fragments ,RC666-701 ,Conventional PCI ,business ,Biomarkers - Abstract
Background Several studies have shown that N-terminal pro-B-type natriuretic peptide (NT-proBNP) is strongly correlated with the complexity of coronary artery disease and the prognosis of patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS), However, it remains unclear about the prognostic value of NT-proBNP in patients with NSTE-ACS and multivessel coronary artery disease (MCAD) undergoing percutaneous coronary intervention (PCI). Therefore, this study aimed to reveal the relationship between NT-proBNP levels and the prognosis for NSTE-ACS patients with MCAD undergoing successful PCI. Methods This study enrolled 1022 consecutive NSTE-ACS patients with MCAD from January 2010 to December 2014. The information of NT-proBNP levels was available from these patients. The primary outcome was in-hospital all-cause death. In addition, the 3-year follow-up all-cause death was also ascertained. Results A total of 12 (1.2%) deaths were reported during hospitalization. The 4th quartile group of NT-proBNP (> 1287 pg/ml) showed the highest in-hospital all-cause death rate (4.3%) (P P = 0.022). NT-proBNP was able to predict the in-hospital all-cause death (area under the curve (AUC) = 0.888, 95% CI = 0.834–0.941, P P Conclusions The increasing NT-proBNP level is significantly associated with the increased risks of in-hospital and long-term all-cause deaths among NSTE-ACS patients with MCAD undergoing PCI. Typically, NT-proBN P > 1568 pg/ml is related to the all-cause and in-hospital deaths.
- Published
- 2020
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