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Objective. To assess the efficacy and safety of amtolmetin guacil (AMG) in patients with knee joint osteoarthritis (KJOA) and associated dyspepsia in real clinical practice. Methods . 220 patients with KJOA with severe pain syndrome in KJ ≥ 40 mm in VAS and dyspepsia were included in the observation study. AMG was administered at a dose of 600 mg twice daily for 28 days. Patients had three visits: before starting treatment, on Day 14 ± 3 (visit 2), on Day 28 ± 3 (final visit) to assess the pain dynamics (according to VAS), stiffness and functional activity according to WOMAC index, general health assessment (according to VAS) and a quantitative assessment of dyspepsia (SODA index). Results. Of 219 patients, about 72.5% reported pain reduction from 65 to 27 mm at the end of the study. All indicators of three scales of the WOMAC index decreased statistically significant (р

Summary. Modern antacids are characterized not only by the capacity to bind hydrochloric acid: they also exert a strong cytoprotective effect which obviously distinguishes them from gastric secretion inhibitors. This is the reason to consider the group of drugs as having combined effect on the pathogenetic mechanisms of erosive and ulcerative lesions of the mucous membranes of the upper gastrointestinal tract. The modern classification of antacids and their role in the treatment of acid-base disorders are demonstrated.

Summary: The article presents the results of a study of bile formation and secretion in various diseases of the gastrointestinal tract. There is a definition of biliary insufficiency syndrome as a polyetiologic set of symptoms typical for a majority of diseases of the digestive system. The leading pathogenetic link in the development of the disease is the change in the amount of bile and reduced secretion of bile acids into the intestine within an hour after the introduction of the stimulant.