1. [Methods of diagnosis of thallium intoxication and its antidote therapy].
- Author
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Shabalina LP, Krillov VF, Spiridonova VS, Poliakova MM, Popova OL, and Shamshinova AM
- Subjects
- Aminolevulinic Acid urine, Capillaries, Electroretinography, Hand blood supply, Humans, Occupational Diseases drug therapy, Poisoning diagnosis, Poisoning drug therapy, Thallium urine, Antidotes, Occupational Diseases chemically induced, Occupational Diseases diagnosis, Thallium poisoning
- Abstract
Absence of early signs specific for thallium intoxication requires objective diagnostic methods. The studies covered 4 techniques: electroretinography (ERG), assessment of urine levels of thallium and delta-aminolevulinic acid, capillaroscopy. The authors supported their previous foundation concerning diagnostic value of ERG for early diagnosis of thallium effects (higher amplitude of b-wave in one and that of a-wave in 8 out of 10 examinees). Further experimental and clinical basis for grading the intoxication through amounts of urinary thallium were found promising. Capillaroscopy method appeared informative: 8 out of 12 examinees demonstrated spastic and atonic state of hand capillaries--that provided objective verification of vascular disorders in workers exposed to thallium and its derivatives.
- Published
- 1996