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Purpose: To evaluate magnetic resonance (MR) signal intensities of orbital pseudotumors on short inversion time inversion-recovery (STIR) images and to predict the effect of treatment., Materials and Methods: Sequential MR examinations were performed in 17 patients with orbital pseudotumors, before and after treatment. All patients underwent MR imaging with T1- and T2-weighted spin-echo or fast spin-echo sequences, and STIR sequences with two 0.5-T systems. Quantitatively and qualitatively, the differences in signal intensities among three therapeutic response groups (good, mild, and no responses) were analyzed for each pulse sequence., Results: Quantitatively, both contrast and contrast-to-noise ratio on STIR images corresponded well to the results of response to therapy for all background markers; contrast and contrast-to-noise ratio values in the good response group were the largest, while those in the no response group were the smallest (P < .0001). Qualitatively, the signal intensities of the lesions in the good response group were interpreted as hyperintense to the cerebral cortex in 14 (93%) or 11 (73%) of 15 lesions by two observers, respectively, while in the no response group, both observers assessed 16 (89%) of 18 lesions as hypo- or isointense to the muscle (P < .0001)., Conclusion: STIR images showed a variety of signal intensities in the lesions, and the signal intensities on the STIR images helped predict the response to the therapy in orbital pseudotumors.