1. Assessment of vascularity in irradiated and nonirradiated maxillary and mandibular minipig alveolar bone using laser doppler flowmetry.
- Author
-
Verdonck HW, Meijer GJ, Laurin T, Nieman FH, Stoll C, Riediger D, Stoelinga PJ, and de Baat C
- Subjects
- Alveolar Process blood supply, Animals, Bicuspid surgery, Dental Arch blood supply, Dental Arch radiation effects, Jaw, Edentulous, Partially pathology, Mandible blood supply, Maxilla blood supply, Microcirculation radiation effects, Molar surgery, Radiation Dosage, Regional Blood Flow radiation effects, Reproducibility of Results, Swine, Swine, Miniature, Tooth Extraction, Alveolar Process radiation effects, Laser-Doppler Flowmetry instrumentation, Mandible radiation effects, Maxilla radiation effects
- Abstract
Purpose: The purpose of this animal study was to confirm that laser Doppler flowmetry (LDF) is a reproducible method for the assessment of maxillary and mandibular alveolar bone vascularity and that there is less vascularity in irradiated mandibular and maxillary bone compared to nonirradiated bone., Materials and Methods: All maxillary and mandibular premolars and molars of 6 Göttingen minipigs were extracted. After a 3-month healing period, 3 minipigs received irradiation at a total dose of 24 Gy. Three months after irradiation, 5 holes were drilled in the residual alveolar ridge of each edentulous site in each minipig. Local microvascular blood flow around all 120 holes was recorded by LDF prior to implant placement. In 1 irradiated and 1 nonirradiated minipig, an additional hole was drilled in a right maxillary site to enable repeated LDF recordings., Results: The alveolar bone appeared less vascularized in irradiated than in nonirradiated minipigs. The effect of radiation appeared more pronounced in the mandible than in the maxilla. LDF was demonstrated to be a reproducible method for assessing alveolar bone vascularity. However, recordings varied by edentulous site as well as by minipig., Conclusion: The authors' hypotheses regarding LDF and vascularity were supported. Further research validating the use of LDF in human beings, especially in those who have undergone radiation therapy for head and neck cancer, is necessary.
- Published
- 2007