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Objective: To investigate the relationship between serum vascular adhesion protein-1 (VAP-1), macrophage stimulating protein (MSP), stromal cellderived factor-1 (SDF-1) levels and pulmonary function, inflammatory factors and quality of life in patients with stable chronic obstructive pulmonary disease (COPD). Methods: 116 patients with stable COPD in our hospital from September 2018 to September 2020 were selected as the COPD group, and 100 healthy volunteers who had physical examination in our hospital during the same period were selected as the control group. The serum VAP-1, MSP, SDF-1 levels, pulmonary function indexes [Forced expiratory volume at 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF)], inflammatory factors [interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-22 (IL-22), tumor necrosis factor-α (TNF-α)] levels were compared between the two groups. According to the severity of patients with stable COPD, they were divided into mild group (n=53), moderate group (n=34) and severe group (n=29). The above indexes were compared among the three groups. The quality of life of the three groups was evaluated and compared by COPD assessment test (CAT), Pearson linear correlation analysis was used to analyze the correlation between serum VAP-1, MSP, SDF-1 levels and pulmonary function, inflammatory factors and CAT score. Results: The serum VAP-1, MSP, SDF-1, IL-6, IL-17, IL-22 and TNF-αlevels in COPD group were higher than those in control group, while FEV1, FVC, FEV1/FVC and PEF were lower than those in control group (P<0.05). Serum VAP-1, MSP, SDF-1, IL-6, IL-17, IL-22, TNF-α levels and CAT score in the mild group were significantly lower than those in the moderate group and severe group, and the moderate group was lower than the severe group, while FEV1, FVC, FEV1/FVC, PEF in the mild group were higher than those in the moderate group and severe group, and the moderate group was higher than the severe group (P<0.05). Pearson linear correlation analysis indicated that serum VAP-1, MSP, SDF-1 levels were negatively correlated with FEV1, FVC, FEV1/FVC, PEF, and the three were negatively correlated with serum IL-6, IL-17, IL-22, TNF-α level and CAT score were positively correlated (P<0.05). Conclusion: The serum VAP-1, MSP and SDF-1 level in patients with stable COPD are significantly up-regulated, and the three are closely related to the patient's pulmonary function, inflammatory factors and quality of life. Clinically, it is expected that the determination of serum VAP-1, MSP and SDF-1 levels, so as to assess the progress of patients with stable COPD. [ABSTRACT FROM AUTHOR]

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