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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective:To explore the expression of signal transducer and activator of transcription 3(STAT3) and B-catenin in the primary hepatocellular carcinoma(HCC) and the relationship with the clinical pathological features of HCC.Methods:Immunohistochemical SP two-step methods was used to detect the expression of the STAT3 and B-catenin in 120 cases of primary hepatocellular carcinoma,30 cases of paracarcinous liver tissue,30 cases of cirrhosis of liver,and 30 cases of normal liver tissue.In addition,the relationship between expressions of STAT3,B-catenin in HCC and the clinicpathologic characteristics was analyzed,and the Spearman was used to explore the correlation of STAT3 and B-catenin in HCC tissues.Results:The STAT3 were expressed in cytoplasm.The positive expression rate of SATA 3 in HCC tissue,paracarcinous liver tissue,liver cirrhosis tissue and normal liver tissue was 64.17%,13.33%,43.33%,and 0.00%,respectively.B-catenin was also expressed in cytoplasm,and the positive expressed rate of B-catenin in HCC tissue,paracarcinous liver tissue,liver cirrhosis tissue and normal liver tissue was 62.50%,16.67%,33.33%,and0.00%,respectively.There were significant difference of positive rate of STAT3 and B-catenin among these groups(P<0.05).The STAT3 expression in HCC was correlated with the age,size of tumor,Alpha fetal protein(AFP),differentiation degree,and vascular tumor emboli(P<0.05).The expression of STAT3 and B-catenin had significant positive correlation in HCC(P<0.05).Conclusion:The STAT3 and B-catenin may play a critical role in the genesis and the development of HCC,and have a significant positive correlation. [ABSTRACT FROM AUTHOR]