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Objective: To explore the effects of Baduanjin combined with resistance exercise on glucose and lipid metabolism, oxidative stress and quality of life in elderly patients with type 2 diabetes (T2DM). Methods: 238 cases of elderly patients with T2DM who were treated in our hospital from April 2021 to May 2022 were selected. According to the method of random number table, they were divided into the control group (on the basis of conventional treatment, they received resistance exercise intervention, 119 cases) and the combined group (on the basis of the control group, they received Baduanjin intervention, 119 cases). The improvement of glucose and lipid metabolism, oxidative stress and quality of life in the two groups were observed. Results: 12 weeks after intervention, body mass index and waist hip ratio in the combined group were lower than those in the control group (P<0.05). 12 weeks after intervention, fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPG) and glycosylated hemoglobin (HbAlc) in the combined group were lower than those in the control group (P<0.05). 12 weeks after intervention, high- density lipoprotein cholesterol (HDL-C) in the combined group was higher than that in the control group (P<0.05), while low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) were lower than those in the control group. 12 weeks after intervention, malondialdehyde (MDA) in the combined group was lower than that in the control group, while superoxide dismutase (SOD) and catalase (CAT) were higher than those in the control group (P<0.05). 12 weeks after intervention, the scores of all dimensions of the MOS 36-item short-form health survey (SF-36) in the combined group were higher than those in the control group (P<0.05). Conclusion: Baduanjin combined with resistance exercise in elderly patients with T2DM can effectively improve the oxidative stress, glucose and lipid metabolism, and improve the quality of life of patients. [ABSTRACT FROM AUTHOR]

Objective: The aim of this work was to investigate the effects of hypoxic ischemic on myelin formation and cytoskeleton of mixed forebrain cells in newborn rats. Methods: The expression of myelin development-related proteins myelin basic protein was verified byimmnnohistochemical staining and Luxol fast blue staining was used to detect the development of myelin sheath and axon in primary cultured mixed forebrain cells; the expression of protein NF155 was verified by Western blotting; the expression of ERM-Rho GTPase related proteins involved in cytoskeleton were verified by imofluorescence analysis. Results: The results showed that hypoxic ischemic inhibited the further differentiation and maturation of mixed cells. The mean density ofMBP, myelin sheath and axon, NF155, Racl and Cdc42 were decreases 57 %, 74 %, 51 %, 81 % and 75 % resperctively. Conclusions: In conclusion the formation of cell processes, the recombination of cytoskeleton were hindered by hypoxic-ischemic-induced, which affected the development and maturation of myelin sheath, and this process is related to the obstruction of cytoskeleton network ERM-Rho GTase signal pathway. [ABSTRACT FROM AUTHOR]

Objective: To explore ketamine(KET)-induced effects on the microglial activation caused by lipopolysaccharide(LPS), and to investigate the role of Suppressor of Cytokine Signaling 1(SOCS1) in the process. Methods: We took N9 microglial cells,and the cells were exposed to the medium containing LPS of 10 ng/mL to mimic inflammation, meanwhile, 1mM of KET was added into the medium. After the treatments of 24 h, western blot, enzyme-linked immunosorbent assay(ELISA), siRNA interfering and immunocytochemistry were taken to assess the activation of microglia and the role of SOCS1 in the process. Results: The cells were divided into three groups, including control group, LPS group and KET+LPS group, after the treatments, we found that LPS increased the inducible nitric oxide synthase(i NOS) protein expression and Tumor Necrosis Factor α(TNF-α) concentration in the medium(P<0.05), and KET reduced the i NOS expression and TNF-α concentration significantly(P<0.05). Then, the cells were divided into five groups, including control group, LPS group, KET+LPS group, SOCS1-siRNA+KET+LPS group and SC-siRNA+KET+LPS group, after 24-h treatments,we found that LPS increased TNF-α and Interleukin-1β(IL-1β) releases and the protein expressions of SOCS1 and nuclear factor-κB(NF-κB), and KET significantly reversed the effects induced by LPS, and increased SOCS1 expression(P<0.05). However, SOCS1-siRNA,not the SC-siRNA, significantly reversed the KET-induced effects above(P<0.05). Conclusions: KET can reduce LPS-induced microglial activation, and SOCS1 protein may mediate the process. [ABSTRACT FROM AUTHOR]

Objective: To study the relationship between serum vascular endothelial growth factor (vascular endothelial, growth factor. YEGF) level and the curative effect of bevacizumab combined with chemotherapy in the treatment of patients with metastatic colorectal cancer. Methods: A total of SO patients with metastatic colorectal cancer, who were admitted to First People's Hospital of Foshan from February 2015 to February 2016, were randomly divided into observation group (n=40) and control group (n=40). The control group was given 5-FU/oxaliplatin (FOLFOX-6), on the basis of which, the observation group wTere treated with bevacizumab(5 mg/kg. dl). The two groups were received 4 cycles of chemotherapy. The clinical curative effect and serum YEGF levels of the patients in the two groups before and after treatment w:ere compared, and the correlation between serum YEGF level and curative effect was analyzed. Results: The effective rate[52.50% (21/40)] of the observation group was significantly higher than that[30.00% (12/40)] of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in serum YEGF level between the two groups before treatment (P>0.05): after treatment, the serum YEGF levels of the two groups were significantly decreased, the serum YEGF level of observation group was significantly lower than that of the control group (P<0.05). The rank correlation analysis showed that there was a significantly positive correlation between the descent range of YEGF and the curative effect after treatment (r=0.683. P=0.000). Conclusion: Bevacizumab combined with chemotherapy in the treatment of metastatic colorectal cancer can significantly reduce the level of serum YEGF. and the curative effect is much better. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the clinical efficacy of inhaled therapy with symbicort turbulaler in the treatment of patients with lung cancer complicated with chronic obstructive pulmonary disease (COPD) and the effect on the quality of life (QOL). Methods: 68 patients with COPD and lung cancer who were treated in our hospital from January 2015 to December 2016 were divided into 2 groups according to the random number table with 34 cases in each group. The control Group was given conventional symptomatic treatment, while the treatment group was additionally given budesonide and foradil powder for inhalation, 2 times per day for 3 months. The changes of percentage of forced vital capacity (FVC%), percentage of forced expiratory volume in 1 second(FEV1%), COPD Assessment Test (CAT), St Georges respiratory questionnaire (SGRQ) in two groups were compared before and after treatment. Results: After treatment, the levels of FVC%, FEV1% in both groups were significantly improved, and which were significantly better than those of the control group (P<0.05). The CAT score, symptom scores, activity score and total score in both group were significantly reduced compared with those before treatment, and which were significantly lower in the treatment group than those of the control group (P<0.05). There was no significant difference in the occurrence of complications between two groups (P>0.05). Conclusions: Inhaled therapy with symbicort turbulaler could effectively improve the lung function and QOL of COPD patients complicated with lung cancer. [ABSTRACT FROM AUTHOR]