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Objective: To investigate the effects of ropivacaine combined with parecoxib sodium serratus plane block (SAPB) on postoperative oxidative stress and immune inflammatory response in patients undergoing thoracoscopic radical resection of lung cancer. Methods: According to the random number table method, 110 patients with lung cancer who underwent thoracoscopic radical resection of lung cancer in The Sixth Affiliated Hospital of Nantong University from January 2021 to April 2023 were divided into observation group (ropivacaine combine with parecoxib sodium SAPB, 55 cases) and control group (ropivacaine SAPB, 55 cases). The postoperative recovery, visual analogue scale (VAS) of pain at rest and cough, immune function, inflammatory response and oxidative stress were compared between two groups, and the incidence of adverse reactions during treatment was observed. Results: The postoperative spontaneous breathing recovery time, eye opening time and extubation time in observation group were shorter than those in control group (P<0.05). The resting VAS and cough VAS in observation group were lower than those in control group 12 h (T2)~48 h (T4) after operation (P<0.05). The levels of superoxide dismutase (SOD), CD3+, CD4+, CD4+/CD8+ in observation group were higher than those in control group at T3 time point. Malondialdehyde (MDA), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and CD8+ were lower than those in control group(P<0.05). The adverse reactions in control group was 7.28%, and that in observation group was 10.92%, with no statistical difference(P>0.05). Conclusion: Ropivacaine combined with parecoxib sodium SAPB for thoracoscopic radical resection of lung cancer, which can effectively improve the clinical symptoms and immune function, reduce the body's inflammatory and oxidative stress. [ABSTRACT FROM AUTHOR]

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Objective: To study the regulation of electroacupuncture Zusanli (ST36) on pulmonary inflammatory response and pathological injury in septic rats, and to provide a new theoretical basis for the clinical treatment of sepsis. Methods: A total of40 adult male SD rats were divided into sham eptic (SHAM group), sepsis group (CLP group), sepsis + sham electroacupuncture group (non-meridian and non-acupoint group) and sepsis + electroacupuncture Zusanli (ST36) group (Zusanli group) according to random number table, with 10 rats in each group. Except for the first group, all the other rats were treated with cecal ligation and perforation (CLP) to prepare the sepsis rat model. Before modeling, the sepsis + sham electroacupuncture group was given by electroacupuncture at non-meridian and non-acupoint points, and the sepsis + electroacupuncture Zusanli (ST36) group was given by electroacupuncture at Zusanli (ST36) points. The parameters of electroacupuncture were density wave, 2 Hz, 1 mA, lasting 30 min for 5 consecutive days. The bronchoalveolar lavage fluid was collected 24 h after surgery, the right lung was collected to measure the wet-dry weight ratio, the lower lobe of the left lung was collected to observe the pathological changes, and the upper lobe of the left lung was collected to detect the inflammatory factors TNF-α, IL-1β, IL-6 and HMGB1. Results: Compared with SHAM group, lung tissue in CLP group showed significant pathological damage (all P<0.05), inflammatory factors were significantly elevated (all P<0.01), and high mobility group protein 1 (HMGB1) was significantly increased (all P<0.05). After electroacupuncture Zusanli (ST36) treatment, the lung pathological injury of sepsis rats was significantly reduced(P<0.05), inflammatory factors were significantly decreased(all P<0.01), and HMGB1 was significantly decreased (P<0.05). There were no significant differences in lung tissue pathological injury, inflammatory factors and HMGB1 between CLP group and non-meridian and non-acupoint group (all P>0.05). Conclusion: Electroacupuncture in Zusanli (ST36) can reduce the Pulmonary inflammation and tissue damage in septic rats, and reduce the level of lung HMGB1. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this work was to investigate the effects of hypoxic ischemic on myelin formation and cytoskeleton of mixed forebrain cells in newborn rats. Methods: The expression of myelin development-related proteins myelin basic protein was verified byimmnnohistochemical staining and Luxol fast blue staining was used to detect the development of myelin sheath and axon in primary cultured mixed forebrain cells; the expression of protein NF155 was verified by Western blotting; the expression of ERM-Rho GTPase related proteins involved in cytoskeleton were verified by imofluorescence analysis. Results: The results showed that hypoxic ischemic inhibited the further differentiation and maturation of mixed cells. The mean density ofMBP, myelin sheath and axon, NF155, Racl and Cdc42 were decreases 57 %, 74 %, 51 %, 81 % and 75 % resperctively. Conclusions: In conclusion the formation of cell processes, the recombination of cytoskeleton were hindered by hypoxic-ischemic-induced, which affected the development and maturation of myelin sheath, and this process is related to the obstruction of cytoskeleton network ERM-Rho GTase signal pathway. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Neutrolphil to lymphocyte ratio（NLR）has been found to be associated with clinic pathological characteristics of many tumors as Immune evaluation index.NLR is concered by researchers for its easy to detect, repeatable, and cheap price. Many studies about breast cancer, colorectal cancer, lung cancer, gastric cancer have revealed the relationship between highly recurrence rate or death rate and NLR. So the study on NLR has great value in diagnose, treatment and prognosis of tumor patient. The mechanism may be related to the promoting effect of neutrophils on tumor and the tumor inhibition of lymphocytes. And the NLR and other inflammatory indexes such as platelet count （Platelet count）, Glasgow outcome score （Glasgow Prognostic, Score, GPS） and carcinoembryonic antigen CEA （carcino-embryonic antigen CEA）, AFP （alpha fetoprotein alpha -fetoprotein, FP or AFP） can be combined for cancer prognosis prediction. As a new indicator, NLR also has shortcomings and deficiencies. This article reviews the applications of NLR in tumors of different systems and the relationship with other diagnose index. [ABSTRACT FROM AUTHOR]

Objective: The present study was designed to explore the role of ER stress in cardiac hypertrophy of adult APPswe/PSldE9 transgenic mice. Methods: 10 adult APPswe/PSIdE9transgenic mice and 10 C57BL/6 wild type (WT) mice were divided into the transgenic experimental and control group. WT experimental and control group, respectively, with 5 mice in each group. Experimental groups received a low dose of Isoproterenol (ISO) (2 mg/kg) once a day for 4 weeks to induce cardiac hypertrophy, while control groups received the same volume of normal saline. After 4 weeks, the mice were anesthetized, followed by. electrocardiogr am (ECG) recording and the measurement of the heart rate and body weight before being sacrificed. The heart was dissected out. and the masses of heart and the left ventricle were measured, the left ventricule mass index (LVW/BW) and the whole heart weight ratio (HW/BW) were calculated. HE staining was used to observe the pathological and morphological changes of cardiornyocytes, and Western Blot and immunohistochemistry were used to detect the expressions of ER stress relevant proteins-GRP78. JNK. P-JNK arrd C'aMKII. Results: Compared with WT experimental mice, the ventricular wall in the APPswc/PSldE9 transgenic experimental mice was apparently hypertrophic after the induction by low doses of ISO. and the HW/BW and the LVW/BW were also significantly increased in the A PPswc/PS IdP.9 transgenic experimental mice than those in the transgenic control mice. WT experimental and control mice (P<0.05). HE staining showed that compared with the transgenic control mice, WT experimental arrd WT control mice, in the adult A PPswc/PS ldF,9 transgenic experimental mice, the cardiomyocyte diameter was obviously increased, cell density was decreased, the capillary density was decreased, the intercellular substance was increased, and the intercellular space was increased. Western blot showed that the expression of GRP78. p-JNK and C'aMKII irr the experimental group of adult APPswe/PSldE9 transgenic mice were sigrrificantly higher than those in the transgenic control mice arrd WT mice (P<0.05 ,P<0.01). There were no significant difference among the control group of transgenic mice and the two groups of WT mice. Immunohistochemistry showed that the positive rates of GRP78 and CaMKH in the cytoplasm of cardiomyocytes of the APPswe/PSldE9 transgenic experimental mice were significantly higher than those of experimental WT mice (80%& 40 %)(P<0.05). and the expressions in the two control groups were negative. The positive rates ofp-JNK and JNK in the APPswc/PSldE9 transgenic experimental mice were 90% and 40% respectively, and the expressions were negative in other three groups. Conclusions: The adult APPswe/PSldE9 transgenic mice are more prone to cardiac hypertrophy than WT mice after the induction with a low dose of ISO. ER stress is involved in the formation of cardiac hypertrophy in adult APPswe /PSldE9 transgenic mice. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the change of serum Omentin-1 level and effect of integrated traditional Chinese and Western medicine on peptic ulcer and h.pylori infection treated first failure. Methods: 82 cases of patients with peptic ulcer who were treated with amoxicillin, omeprazole, azithromycin combined with Qingyou oral solution in our hospital from September 2011 to September 2015 were selected as objects, and 20 cases of healthy people were selected as control group. Using ELISA method to detect the plasma levels of Omentin-1, the relationship between plasma levels of Omentin-1 and nitric oxide(NO), interleukin-2(IL-2), endothelin-1(ET-1), tumor necrosis factor alpha(TNF-α) were analyzed. The change of plasma levels of Omentin-1, the efficacy and safety of integrated traditional Chinese and Western medicine were observed. Results: After traditional Chinese and western medicine treatment, h. pylori eradication rate was 88.6%, 34 cases recovered, 22 cases effective, 33 cases valid, 3 cases ineffective, the healing rate was 68.29%(56/82), and the effective rate was 96.34%(79/82); theplasma level of Omentin-1in observation group was(18.15 ± 3.96) ng/mL, significantly lower than the control group(23.12 ± 6.03) ng /mL(P<0.05); compared with control group, the NO, IL-2 level of observation group was obviously lower(P< 0.05), ET-1, TNF-α and IL-6 level wasincreased significantly(P<0.05); compared with before treatment, after combined Chinese and western medicine treatment, NO, IL-2 level was significantly decreased(P< 0.05), and the ET-1, TNF-α and IL-6level was increased significantly(P< 0.05); the Omentin-1 level was significantly positively correlated with IL-2, NO(r = 0.412, P< 0.05 and r = 0.382, P< 0.05), and negatively correlated with IL-6 and TNF-α(r = 0.246, P< 0.05 and r = 0.258, P< 0.05). Conclusions: The integrated traditional Chinese and Western medicine can increase the plasma levels of Omentin-1 in patients with peptic ulcer and h.pylori infection, effectively improve the ulcer healing rate and H.pylori eradication rate, inhibit the secretion of inflammatory cytokines,enhance endogenous NO protection and the body's immune function. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analyze the correlation of hs-CRP and the deep vein thrombosis (DVT), so as to explore the role of inflammation in the occurrence and development of DVT. Methods: 113 patients with DVT who were treated in our hospital from September 2013 to March 2015 were chosen. According to the disease sites, they were divided into the central, the peripheral and the hybrid. According the onset time, they were divided into the acute, the subacute and the chronic. And another 50 healthy volunteers who had taken the examination at the same time in our hospital selected as the control group. Then the levels of hs-CRP were measured. Results: The hs-CRP in DVT plasma was higher than normal healthy people (P<0.05). The hs-CRP levels in patients with DVT of different clinical classifications were significantly different, and the hybrid was the highest, the peripheral was the lowest, and the differences were statistically significant (P<0.05). The hs-CRP levels in patients with DVT of different disease stage were significantly different, and the acute was the highest, the chronic was the lowest, and the differences were statistically significant (P<0.05). The hs-CRP levels increased after the thrombolytic therapy for 3 days, and decreased after the thrombolytic therapy for 5 days. Conclusion: The hs-CRP levels of patients with DVT could be an index for clinical diagnosis, which might be relative to the incidence and progress of DVT. [ABSTRACT FROM AUTHOR]