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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the efficacy of Hehuan Jieyu Decoction combined with milnacipran in the treatment of elderly patients with depression, and to analyze the effect of treatment on the level of hypersensitive C-reactive protein (hs-CRP) in patients.Methods: Eighty elderly patients with depression who received treatment in our hospital from February 2021 to January 2022 were selected as the research object, and they were divided into an experimental group and a control group (40 patients in each group) according to the random number table method. Patients in the control group were treated with esccitalopram oxalate tablets, and patients in the experimental group were treated with Hehuan Jieyu Decoction on the basis of the control group. The therapeutic effects of the two groups were compared. The Hamilton Depression Scale (HAMD) and Pittsburgh Sleep Quality Index (PSQI) before and after treatment, Suicide Ideas Self-Assessment Scale (SIOSS), interleukin-6 (IL-6), hs-CRP levels, and record and compare the incidence of adverse reactions in the two groups of patients during treatment. Results: The effective rate of treatment in the experimental group was 97.50% and that in the control group was 85.00 %. The difference between the two groups was significant (P＜0.05). The HAMD and PSQI scores of the two groups before treatment were not different. The scores of the above-mentioned scales in the experimental group were lower than those in the control group (P＜0.05). The scores of the SIOSS scales of the two groups before treatment were not different (P＞0.05). After treatment, the despair factor and optimism of the patients in the experimental group The scores of factor, sleep factor and concealment factor were lower than those of the control group (P＜0.05). The levels of IL-6 and hs-CRP of the two groups of patients before treatment were not different (P＞0.05). IL-6 and hs-CRP levels were lower than those of the control group (P＜0.05). There was no difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion: Hehuan Jieyu Decoction combined with milnacipran has a good therapeutic effect on senile depression, which can significantly improve patients’ depressive symptoms, reduce their suicide risk and inflammatory factor levels, and at the same time, the treatment is safer. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between intestinal flora imbalance and depression with coronary heart disease, and analyze the predictive value of intestinal flora imbalance on the prognosis of depression with coronary heart disease. Methods: 80 patients with depression admitted to our hospital from June 2021 to May 2022 were selected as the research objects. 49 patients with simple depression were divided into depression group, 31 patients with coronary heart disease were divided into depression and coronary heart disease group, and 40 healthy people who came to our hospital for physical examination at the same time were selected as the control group to compare the intestinal flora of the three groups, Spearman correlation analysis was used to analyze the correlation between intestinal flora imbalance and depression with coronary heart disease. Subsequently, 31 patients with depression and coronary heart disease were followed up, and they were divided into good prognosis group (n=21) and poor prognosis group (n=10). The clinical general conditions and intestinal flora of the two groups were compared, and the prognostic value of intestinal flora for depression and coronary heart disease was analyzed by logistic regression analysis. Results: There was no difference in Bacteroides among the three groups (P>0.05). There was a difference in the comparison of Enterobacteriaceae, Enterococcus. Bifidobacterium, Lactobacillus and B/E values. The levels of Enterobacteriaceae and Enterococcus in the depression with coronary heart disease group were higher than those in the depression group and the control group, and the values of Bifidobacterium, Lactobacillus and B/E were lower than those in the depression group and the control group (P<0.05); Spearman correlation analysis showed that there was no significant correlation between the level of Bacteroides in intestinal dysbacteriosis and depression with coronary heart disease (P>0.05). The levels of Enterobacteriaceae and Enterobacteriaceae in intestinal dysbacteriosis were positively correlated with depression with coronary heart disease, and negatively correlated with the logarithmic ratio (B/E) of the number of Bifidobacterium, Lactobacillus, Bifidobacteriaceae and Enterobacteriaceae (P<0.05); There was no difference in the scores of hs cTnT, NT proBNP, NT proBNP, PHQ-9 and Bacteroides between the group with good prognosis and the group with poor prognosis, age, BMI, concomitant basic diseases (P>0.05), but there was difference in hs CRP, Enterobacteriaceae. Enterococcus, Bifidobacterium, Lactobacillus and B/E values (P<0.05): Logistic regression analysis showed that only hs CRP and B/E value dysbacteriosis had independent predictive value for the prognosis of depression with coronary heart disease (P<0.05). Conclusion: The proportion of intestinal flora in patients with depression combined with coronary heart disease is more imbalance than that in patients with single depression and healthy people, and the imbalance of intestinal flora is significantly related to depression combined with coronary heart disease. The application of B/E value can predict the prognosis of patients with depression combined with coronary heart disease. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the relationship between the use intensity of antibiotics and the resistance of Acinetobacter baumannii in our hospital from 2015 to 2018. Methods: The application of antibiotics in our hospital from January 2015 to December 2018 and the resistance of Acinetobacter baumannii were analyzed. The drug resistance data of Acinetobacter baumannii come from the pathogenic samples such as wound secretion, sputum, blood, urine, etc. Results: From 2015 to 2018, a total of 13246 strains were isolated, of which 1927 strains were Acinetobacter baumannii, with the isolation rate of 14.55%. The separation rate was 3.11 % in 2015, 4.51 % in 2016, 5.15 % in 2017 and 2.11 % in 2018. The highest isolation rate of Acinetobacter baumannii was sputum (78.83 %), followed by wound secretion (12.51 %), urine (5.81 %), blood (2.85 %). Acinetobacter baumannii ranked first or second among all pathogenic bacteria in our hospital; the use intensity of antibiotics increased year by year from 2015 to 2018, and decreased in 2018. From 2015 to 2018, the drug resistance rate of Acinetobacter baumannii to piperacillin, tazobactam, meropenem and imipenem increased year by year, and decreased in 2018, there was a significant correlation between the drug resistance of piperacillin, tazobactam and imipenem and the intensity of antimicrobial use (P<0.05). Conclusion: The use of piperacillin sodium, tazobactam sodium, meropenem and imipenem is one of the important reasons for resistance of Acinetobacter baumannii. We should pay attention to it in clinical practice. [ABSTRACT FROM AUTHOR]

The study was preformed to investigate the expression pattern of intracellular double-stranded DNA sensors in human trophoblast cells and its effect on the secretion of inflammatory factors, to reveal the immune recognition and immune barrier function of placenta, and to better understand the pathogenesis of adverse pregnancy outcomes caused by pregnancy infection. Synthetic double-stranded DNA (dsDNA) mimics, poly (dA:dT), were transfected into human trophoblast cell line HTR-8/SVneo, double-stranded DNA sensors' mRNA were detected by quantitative real-time PCR and the phosphorylation levels of MAPK and I资B signaling were detected by Western Blot. ELISA was used to detect IL-6, IL-8, MCP-1 and CXCL10 secretion. Real-Time PCR results showed that IFI16, AIM2, DHX36, DHX9, LRRFIP1, KU70, ZBP1/DAI and DDX41 mRNA levels were dramatically upregulated in HTR-8/SVneo cells. The phosphorylation levels of ERK, JNK, p38 and I资B were elevated at 90 minutes after poly (dA:dT) transfection, and then gradually decreased. The induction of IL-8, IL-6 and CXCL10 secretion is dependent on I资B, p38 and JNK signaling pathways; MCP-1 secretion is dependent on p38 and JNK signaling pathways. However, these cytokines and chemokines were not affected by ERK inhibitor. Human placental trophoblast cells express functional intracellular double-stranded DNA sensors, which can recognize double-stranded DNA and activate MAPK/I资B signaling pathways that mediate the secretion of IL-8, IL-6, MCP-1 and CXCL10. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of the C- reactive protein, MCP-1 and MMP-9 levels in peripheral blood by erigeron breviscapus oral liquid in patients with acute coronary syndrome. Methods: 110 patients with acute coronary syndrome from department of Cardiology in our hospital were selected and randomly divided into the control group and the experiment group. The C- reactive protein, MCP-1 and MMP-9 levels in peripheral blood were tested and compared before and after treatment. Results: Compared with before treatment, the levels of MCP-1, MMP-9 and C- reactive protein were lower (P<0.05). Compared with the control group after treatment, the levels of MCP-1, MMP-9 and C- reactive protein were lower (P<0.05), the total effective rate were higher (P<0.05). Conclusion: Erigeron breviscapus oral liquid can reduce the acute coronary artery syndrome in patients with peripheral blood C reactive protein, MCP-1 and MMP-9 levels, of acute coronary artery comprehensive syndrome clinical treatment has important clinical significance. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Colonoscopy had been considerably developed in maneuvers and instruments since the late nineteen sixties.It made the visualization,biopsy and treatment of intestine possible without laparotomy.Though its application had brought dramatic benefits for the diagnoses and treatments of colorectal diseases and became the gold standard for primary investigation of colorectal cancer,its limitations including unavoidable pain,unpredictable complications,impossibility of guaranteed intubation of the cecum and errors in colonoscopic detection of neoplasia appeared to be more and more obvious and made itself restricted,which negatively affected the patients’ compliance with the examine and increased the difficulty during the procedure.What was worse,some of them may miss the treatment which should have been available before.The clinical applications of conventional colonoscopy was reviewed so as to provide guidelines for the reasonable application of conventional colonoscopy hereafter. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of intratympanic injection of steroids hormones in treatment of elderly patients with sudden deafness. Methods: A total of 94 elderly patients with sudden deafness, who were admitted to Hebei People's Hospital, were divided into intratympanic group and intravenous group according to different ways of drug delivery. The intratympanic group w:as treated with intratympanic injection of steroid hormone: the venous group, intravenous injection of steroid hormone. The clinical efficacy differences of the two groups were compared and analyzed. Results: The total effective rate (75%) of the intratympanic group was higher than that (55.26%) of the intravenous group, there was statistical difference in the total effective rate between the two groups (P<0.05). The total effective rates of intratympanic group and intravenous group of patients with systemic diseases were 55.56% and 36.00%. respectively, the differences were statistically significant ( X3=5.5877. P=0.016). Conclusion: Compared with intravenous injection of steroids hormones, intratympanic injection of steroids hormones has better clinical efficacy in the treatment of elderly patients with sudden deafness, especially for the elderly patients with diabetes, high blood lipids. [ABSTRACT FROM AUTHOR]

Diabetic mellitus is a kind of chronic disease threatening people’s health. Microvascular lesions is the specificity of diabetes disease, the complications including nephropathy, retinopathy and neuropathy. The occurrence of diabetic microvascular lesion development is influenced by many factors, the mechanism of research has formed a variety of theories, such as the enzyme glycosylated chemical, polyol pathway, oxidative stress and hexose amine path theory, etc. In recent years, lipoic acid for the treatment of diabetic microvascular complications is the hot spot in home and abroad. Lipoic acid is powerful antioxidant. Their functions include: scavenging free radicals and reactive oxygen species, and regeneration of exogenous and endogenous antioxidants such as glutathione in the body.They are attenuate the oxidative stress reaction. Lipoic acid also decrease causative factor resulting in complication of diabetic microangiopathy, and intervene in the polyol pathway and hexose amine pathway and exert protective effect on target organ. In this paper, lipoic acid in diabetic microangiopathy application to do a brief overview. [ABSTRACT FROM AUTHOR]