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Objective: To investigate effect of bi-level positive airway pressure combined with seretide on immune function, quality of life and respiratory failure symptoms of patients with COPD complicated with type II respiratory failure. Methods: 157 patients with COPD complicated with type II respiratory failure in our hospital from June 2012 to December 2016 were divided into observation group (n=79) and control group (n=78) according to the random number table method, the patients in the control group were treated with routine treatment such as relieving asthma, relieving spasm, resolving phlegm and anti infection, and combined with Bi-PAP treatment, the patients in the observation group were treated with seretide treatment on the basis of the treatment plan in the control group. Respiratory failure symptoms, immune function and quality of life were compared between the two groups before and after treatment. Results: The effective rate of the observation group after treatment was 89.87% (71/79), which was significantly higher than that of the control group 73.08%(57/78)(P<0.05). After treatment, the respiratory rate, heart rate, arterial partial pressure of carbon dioxide in the two groups were lower than before treatment, and the arterial partial pressure of oxygen was higher than before treatment, and the respiratory rate, heart rate and arterial partial pressure of carbon dioxide in the observation group were lower than those in the control group, and the arterial partial pressure of oxygen was higher than that of the control group (all P<0.05). After treatment, levels of serum immunoglobulin M (IgM),immunoglobulin G (IgG) and immunoglobulin A (IgA) of patients in two groups were significantly higher than those before treatment, and the levels of IgM, IgA and IgG in the observation group after treatment were higher than those in the control group (all P<0. 05). Over time, the St.George Hospital Respiratory Questionnaire (SGRQ) score in the two groups after treatment was decreased gradually, and the SGRQ scores of the observation group at 3 months and 6 months after treatment were lower than that of the control group (all P<0.05). Conclusion: Bi-PAP combined with Seretide can significantly improve the symptoms of respiratory failure in patients with COPD complicated with type II respiratory failure, improve immune function and quality of life of patients, clinical application value is high. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical efficacy and safety of posterior vertebral pedicle screw fixation in the treatment of thoracolumbar burst fracture. Methods: 64 cases of thoracolumbar burst fracture treated in our hospital from January 2014 to December 2016 were selected.which were divided into study group (n=32) and control group (n=32). The study group was treated by posterior vertebral pedicle screw fixation, the control group was treated by posterior vertebral pedicle screw pedicle screw fixation. The patients were followed up for 6 months. The clinical indicators, complications were compared between the two groups. The height ratio of anterior margin of injured vertebra, Cobb angle and Numeric Pain Rating Scale (NRS) scores of the two groups before operation. 1 month after operation. 6 months after operation were compared. Results: All the patients were all healed in I stage and no infection after operation. Compared with the control group, the operation time of the study group was longer (P<0.05), and there was no significant difference between the amount of bleeding and the time of hospitalization (P>0.05). There was no significant difference between the height ratio of anterior margin of injured vertebra. Cobb angle and NRS scores of the two groups (P>0.05). 1 month after operation. 6 months after operation, the height ratio of anterior margin of injured vertebra in the two groups were higher than before operation. Cobb angle and NRS scores were lower than before operation, the differences were statistically significant (P<0.05). 6 months after operation, the Cobb angle. NRS scores in the study group were lower than that in the control group (P<0.05). and there was no significant difference in the height ratio of anterior margin of injured vertebra of the two groups (P>0.05). Compared with the control group, the incidence rate of lumbago and back pain and internal fixation failure in the study group were lower than that in the control group (P<0.05). Conclusion: For thoracolumbar burst fractures .posterior vertebral pedicle screw fixation can effectively improve clinical indicators, is conducive to postoperative physical recovery.pain relief and safety, and is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy and mechanism of action of retention enema Qing Yi Decoction combined with ERCP in the treatment of acute cholinergic pancreatitis. Methods: 97 cases of patients with acute cholinergic pancreatitis from Jan. 2015 to Dec. 2017 in our hospital were selected and divided into the control group (ERCP, 46 cases) and the observation group (retention enema Qing Yi Decoction combined with ERCP, 53 cases) according to different treatment methods. The clinical efficacy of TCM between the two groups were observed and compared. The levels of serum TNF-α, CRP, IL-6, IL-8, IL-10, amylase, abdominal pain relief time, average hospitalization time and average hospitalization cost were observed and compared before and at 12 h, 24 h, 7 days after treatment. Results: After treatment, the cure rate and markedly effective ratio of observation group were significantly higher than those of the control group (P<0.05). The levels of serum TNF-α, CRP, IL-6, IL-8 and IL-10 in the two groups were significantly lower than those before treatment, and the levels of serum TNF-α, CRP, IL-6 and IL-8 in the observation group were significantly lower than those in the control group (P<0.05); there was no significant difference in the average hospitalization expense between the two groups (P>0.05); the abdominal pain relief time and the average hospitalization time in the observation group were significantly lower than those in the control group (P<0.05). Compared with those before treatment, the serumamylase levels of both groups at 12 h, 24 h and 3 d after treatment were significantly decreased, and the serum amylase levels of observation group at 12 h and 24 h after treatment were significantly lower than those of the control group (P<0.05). Conclusion: Retention enema Qing Yi Decoction combined with ERCP treatment could significantly improve the heal and efficacy rate of acute cholinergic pancreatitis, and its mechanism may be related to the reduction of serum TNF-α, CRP, IL-6, IL-8 and amylase levels. [ABSTRACT FROM AUTHOR]

Objective: To study the expression of CD44 and CD24 in breast cancer tissues and their relationship with clinicopathological features. Methods: A total of 80 patients with breast cancer, who were received surgical treatment in Cangzhou People’s Hospital of Hebei Province from January 2015 to January 2017, were enrolled in this study; 30 patients with ductal carcinoma in situ, 20 patients with lobular hyperplasia, 20 patients with simple ductal hyperplasia,admitted to in this hospital in the same period, were selected. Specimens were extracted from cancer patients and hyperplastic patients and compared. The expression of CD44 and CD24 in breast cancer tissues and different lesion types were analyzed, and the expression of CD44+/CD24-cells in the cancer immune typing and the relationship between CD44+/CD24- cells and the pathological features of breast invasive ductal carcinoma were analyzed. Results:The positive expression rates of CD44 and CD24 in breast cancer tissues were 52.50% and 57.50%, respectively, which were significantly higher than those(11.25% and 15.00%) in the adjacent tissues, the difference was statistically significant(P<0.05).The positive rates of CD44 and CD24 in ductal carcinoma in situ and in breast invasive ductal carcinoma were higher than those in lobular hyperplasia and in simple ductal hyperplasia, the positive rate of ductal carcinoma in situ was higher than that of breast invasive ductal carcinoma,the difference was statistically significant(all P<0.05).The positive rate of CD44 in different types of breast invasive ductal carcinoma was statistically significant(P<0.05), and there was no significant difference in the positive rate of CD24 in different types of breast invasive ductal carcinoma(P>0.05). There were significant differences in the positive rates of CD44+/CD24- cells in different types of cancer immunology and differentiation(P<0.05). There was no significant relationship between CD44+/CD24- cells and age, menstrual status, tumor size, lymph node metastasis and distant metastasis in patients with breast invasive ductal carcinoma(P<0.05). Conclusion:CD44 and CD24 have higher positive expression rate in breast cancer tissues, and CD44+/CD24- has a higher positive expression rate in breast carcinoma in situ and poorly differentiated breast invasive ductal carcinoma. The patient’s condition and prognosis were evaluated by monitoring the positive expression of CD44+/CD24- in clinic. [ABSTRACT FROM AUTHOR]

Objective: To study the adverse effect and mechanisms of diflufenican on rat testis, and try to provide the experimental evidence for improving the safety evaluation and protective measures of this new herbicide. Methods: Male SD adult rats had been given 0, 20, 100, 500 mg/kg of diflufenican for 90 days. The general toxicities were observed, and the serum GSH, T-AOC, SOD were measured, Besides, the pathological trauma of testis of rats was observed, and the protein expressions of Cleaved-caspases 3, C-PRAR, FAS/FASL in testicular tissue were detected by immunoblotting, and further validated by immunohistochemical assay. Results: Compared with control group, the middle and high doses of diflufenican groups obviously reduced the ponderal growth and food utility rate of rat （P<0.05）, and depressed either serum SOD （P<0.05）or T-AOC levels except for GSH. In addition, the pathological observation in contaminated rat testis showed the vacuolation in seminiferous tuble and spermatophore reduce in lumen. Subsequently, the expressions of Cleaved-caspases 3, C-PRAR, FAS in rat testis remarkably increased, which was confirmed by immunohistochemistry results that the Cleaved-caspases 3 positive cell population in rat seminiferous tubule obviously increased in low and high contamination groups (P<0.05). Conclusions: Diflufenican can decline oxidation resistance in rat testis, which indicated that the testis might be the potential target of this kind of herbicide. Oxidative stress pathway might contribute to the diflufenican-induced male reproductive toxicity. [ABSTRACT FROM AUTHOR]