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Objective: To investigate the effects of hyperbaric oxygen combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) on wake-promoting effect, neuroelectrophysiology and brain injury markers in patients with disturbance of consciousness (DOC) after severe craniocerebral injury. Methods: 80 patients with DOC after severe craniocerebral injury who were admitted to Lu'an Hospital Affiliated to Anhui University of Traditional Chinese Medicine from June 2021 to June 2023 were selected. Patients were divided into control group (n=40, hyperbaric oxygen therapy ) and observation group (n=40, hyperbaric oxygen combine with high-frequency rTMS therapy) according to the random number table method. Control group received hyperbaric oxygen therapy, and observation group received hyperbaric oxygen combine with high-frequency rTMS therapy. The efficacy, wake-promoting effect, neuroelectrophysiology and brain injury markers were compared between two groups. Results: The total clinical effective rate in observation group was higher than that in control group(P<0.05). The scores of revised coma recovery scale (CRS-R) and Glasgow coma scale (GCS) in two groups increased 4 weeks after treatment, and observation group was higher than that of control group (P<0.05). The brainstem auditory evoked potential (BAFP), four limb sensory evoked potential (SEP) and electroencephalogram (EEG) grading were improved in two groups 4 weeks after treatment, and the improvement effect in observation group was better than that in control group (P<0.05). Myelin basic protein (MBP), neuron-specific enolase (NSE) and S100β protein decreased in two groups 4 weeks after treatment, and observation group was lower than that of control group(P<0.05). Conclusions: Hyperbaric oxygen combined with high-frequency rTMS therapy can effectively wake up patients with DOC after severe craniocerebral injury, improve neuroelectrophysiological activities, and reduce the degree of brain injury. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)