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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between the expression of serum miR-203 and miR-217 and the efficacy and prognosis of patients with acute myeloid leukemia. Methods: 101 patients with acute myeloid leukemia treated in our hospital from April 2010 to April 2014 were selected as the AML group. The AML group was further divided into the complete remission group and the relapse group according to the treatment effect, and 101 healthy patients who underwent physical examination in our hospital during the same period were selected as the healthy group. The expression levels of serum miR-203 and miR-217 in each group were detected by fluorescence quantitative PCR, and the relationship between the expression levels of serum miR-203 and miR-217 and the clinicopathological features of the patients was analyzed. Kakaplan-Meier method was used to analyze the survival of AML patients with different serum miR-203 and miR-217 levels. Results: Compared with the healthy group, the serum miR-203 and miR-217 levels in the AML group were significantly lower (P<0.05). Compared with the complete response group, the serum miR-203 and miR-217 levels in the relapse group were significantly lower(P<0.05). Serum miR-203 levels were associated with leukocyte count in AML patients (P<0.05), while serum miR-217 levels were associated with platelet count in AML patients(P<0.05). The 5-year survival rate of AML patients with relatively high expression of serum miR-203 and miR-217 was higher than those with relatively low expression of serum miR-203 and miR-217, respectively (Log RankmiR-203=17.870, Log RankmiR-217=28.926, all P=0.000). Conclusion: The expression levels of serum miR-203 and miR-217 are closely related to AML. Detection of serum miR-203 and miR-217 expression levels might be helpful in evaluating the efficacy and prognosis of AML patients. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between the expression of cyclooxygenase-2 (COX-2), succinate dehydrogenase (SDHB), heat shock protein 90β (HSP90β) and the clinicopathological characteristics and prognosis of nasopharyngeal carcinoma. Methods: The expression of COX-2, SDHB and HSP90β in 78 cases of nasopharyngeal carcinoma tissue and 65 cases of chronic inflammation of nasopharynx were detected by immunohistochemistry, and the relationship between the expression of COX-2, SDHB and HSP90β and the clinicopathological characteristics of NPC was analyzed. All patients were followed up for 3 years. According to the expression of COX-2, SDHB and HSP90β, the patients were divided into COX-2 positive group, COX-2 negative group, SDHB positive group, SDHB negative group, HSP90β positive group and HSP90β negative group. Results: The positive rate of COX-2 and HSP90β in nasopharyngeal carcinoma tissue was significantly higher than that in nasopharynx, and the positive rate of SDHB was significantly lower than that in nasopharynx (P<0.05). The positive rates of COX-2 and HSP90β in nasopharyngeal carcinoma tissue with TNM stage III+IV, middle and low differentiation and cervical lymph node metastasis were significantly higher than those TNM stage I+II, high differentiation and no cervical lymph node metastasis, and the positive rates of SDHB were significantly lower than those in nasopharyngeal carcinoma tissue with TNM stage I + II, high differentiation and no cervical lymph node metastasis (P<0.05). Spearman correlation analysis showed that COX-2 expression was negatively correlated with SDHB expression (rs=-0.462, P=0.008), positively correlated with HSP90β expression (rs=0.501, P=0.000), and SDHB was negatively correlated with HSP90β expression (rs=-0.438, P=0.012). After 3 years follow-up, 49 cases survived and 29 died, with a survival rate of 62.82%. The survival rate and median survival time of patients in COX-2 negative group, SDHB positive group and HSP90β negative group were significantly better than those in COX-2 positive group, SDHB negative group and HSP90β positive group (P<0.05). Conclusion: The expression of COX-2, SDHB and Hsp90β in NPC is related to TNM stage, tumor differentiation and cervical lymph node metastasis, and its expression is closely related to the survival period of NPC patients. [ABSTRACT FROM AUTHOR]

To investigate the influence of the improved vascular intubation and the end to end vascular anastomosis on the blood circulation, survival and motor function of severed fingers in patients with replantation. The clinical data of 107 cases of patients with replantation of severed fingers who were treated in our hospital from January 2017 to December 2018 were retrospectively selected. According to the different operative methods, the patients were divided into group A (n=55, 93 severed fingers in total) and group B (n=52, 86 severed fingers in total). Group A was treated with end to end vascular anastomosis, and group B was treated with improved vascular intubation. The blood circulation, survival, motor function, quality of life and complications of the two groups were compared. The filling time of capillaries and microcirculation of the affected fingers test value in group B were lower than those in group A, while the oxygen saturation and transcutaneous oxygen partial pressure were higher than those in group A (P<0.05). The survival rate, normal tension rate and normal color rate of severed fingers in group B were higher than those in group A (P<0.05). The scores of physiological field, social relationship field, psychological field and environmental field in group B at 1 year after operation were higher than those in group A (P<0.05). The scores of activity, muscle strength, dexterity and Carroll scale in group B were higher than those in group A (P<0.05). There were no significant differences in the incidence of complications between the two groups (P>0.05). Compared with the method of end to end vascular anastomosis, improved vascular intubation for replantation of severed fingers, it the improvement effect is better in the aspects of blood circulation, survival, motor function and quality of life of severed fingers, and will not increase the incidence of complications. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the clinical efficacy of Yinzhihuang granules combined with blue light in the treatment of neonatal pathological jaundice and the effect on myocardial enzymes. Methods: 80 cases of patients with neonatal pathological jaundice treated in our hospital from February 2015 to December 2016 were randomly divided into two groups(control group and observation group), with 40 cases in each group. All patients were given routine treatment according to the clinical symptoms, and patients in control group were treated with blue light irradiation. Patients in the observation group were treated with Yinzhihuang granules combined with blue light irradiation. Both groups were treated continuously for one week. The clinical efficacy, serum myocardial enzymes, bilirubin levels and incidence of adverse reactions of two groups were compared. Results: Before treatment, there was no significant difference in the serum total bilirubin(TBIL) and direct bilirubin(DBIL) levels between the two groups(P>0.05). After treatment, the levels of serum bilirubin in both groups were both significantly decreased(P<0.05), and the TBIL and DBIL levels in the observation group were significantly lower than those in the control group. Before treatment, there was no significant difference in the serum lactate dehydrogenase(LDH), creatine kinase(CK) and creatine kinase isoenzyme(CK-MB) between the two groups(P>0.05). After treatment, the levels of myocardial enzymes of both groups were significantly decreased(P<0.05), and the LDH, CK and CK-MB levels in observation group were significantly lower than those of the control group(P<0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Yinzhihuang granules combined with blue light can significantly improve the clinical efficacy, the serum bilirubin, the myocardial enzyme spectrum, and is more secure in the treatment of neonatal jaundice compared with the treatment of blue light irradiation alone. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)