1. Leukocyte Subtype Counts and Its Association with Vascular Structure and Function in Adults with Intermediate Cardiovascular Risk. MARK Study
- Author
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Jose-Angel Maderuelo-Fernandez, Luis Garcia-Ortiz, ANGELA DE CABO-LASO, Carmen Patino-Alonso, Núria Pagès Cadena, Jose I Recio-Rodriguez, Dídac Parramon, Miquel Quesada Sabaté, Manuel A Gomez-Marcos, Christodoulos Stefanadis, Ruth Martí Lluch, and Rafel Ramos
- Subjects
Male ,Cross-sectional study ,Neutrophils ,humanos ,lcsh:Medicine ,Blood Pressure ,Carotid Intima-Media Thickness ,Monocytes ,chemistry.chemical_compound ,Leukocyte Count ,Vascular stiffness ,rigidez vascular ,Sex factors ,Risk Factors ,análisis de regresión ,Leukocytes ,lcsh:Science ,Pulse wave velocity ,mediana edad ,anciano ,Multidisciplinary ,Middle Aged ,adulto ,Cardiovascular Diseases ,Cardiology ,cardiovascular system ,Regression Analysis ,Female ,Research Article ,Adult ,presión sanguínea ,medicine.medical_specialty ,leucocitos ,enfermedades cardiovasculares ,Pulse Wave Analysis ,neutrófilos ,Sex Factors ,Vascular Stiffness ,recuento de leucocitos ,Internal medicine ,medicine ,Humans ,factores de riesgo ,grosor de la íntima y media carotídea ,Vascular structure ,Ankle Brachial Index ,cardiovascular diseases ,análisis de la onda del pulso ,Aged ,Cholesterol ,business.industry ,lcsh:R ,Blood pressure ,Cross-Sectional Studies ,chemistry ,monocitos ,Immunology ,lcsh:Q ,business ,estudios transversales ,índice tobillo-brazo - Abstract
Objectives We investigated the relationship between leukocyte subtype counts and vascular structure and function based on carotid intima-media thickness, pulse wave velocity, central augmentation index and cardio-ankle vascular index by gender in intermediate cardiovascular risk patients. Methods This study analyzed 500 subjects who were included in the MARK study, aged 35 to 74 years (mean: 60.3 +/- 8.4), 45.6% women. Measurement: Brachial ankle Pulse Wave Velocity (ba-PWV) estimate by equation, Cardio-AnkleVascular Index (CAVI) using the VaSera device and Carotid ultrasound was used to measure carotid Intima Media Thickness (IMT). The Mobil-O-Graph was used to measure the Central Augmentation Index (CAIx). Results Total leukocyte, neutrophil and monocyte counts were positively correlated with IMT (p < 0.01) in men. Monocyte count was positively correlated with CAIx in women (p < 0.01). In a multiple linear regression analysis, the IMT mean maintained a positive association with the neutrophil count (beta = 1.500, p = 0.007) in men. CAIx maintained a positive association with the monocyte count (beta = 2.445, p = 0.022) in women. Conclusion The results of this study suggest that the relationship between subtype circulating leukocyte counts and vascular structure and function, although small, may be different by gender. In men, the neutrophil count was positively correlated with IMT and in women, the monocyte count with CAIx, in a large sample of intermediate-risk patients. These association were maintained after adjusting for age and other confounders., This work was supported by grants funded by the Spanish Ministry of Science and Innovation (MICINN) and Carlos III Health Institute/European Regional Development Fund (ERDF) (MICINN, ISCIII/FEDER) (Red RedIAPP RD06/0018, Research Groups: RD06/0018/2009, RD06/0018/0045/RD06/0018/0027) and by the Health Research Fund(FIS PI10/01088, PI10/02077, PI10/02043) and Regional Health Management of the Castilla and Leon(GRS 635/A/11). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Published
- 2015