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Your search keyword '"Toyoshi Umezu"' showing total 2 results
Start Over Author "Toyoshi Umezu" Publisher public library of science (plos)
2 results on '"Toyoshi Umezu"'

1. l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice.

Author

Toyoshi Umezu, Tomoharu Sano, and Junko Hayashi

Subjects
Medicine, Science
Abstract

Similar to psychostimulants, the peripheral administration of menthol promotes mouse motor activity, and the neurotransmitter dopamine has been suggested to be involved in this effect. The present study aimed to elucidate the effects of l-menthol on parts of the central nervous system that are involved in motor effects. The subcutaneous administration of l-menthol significantly increased the number of c-Fos-like immunoreactive nuclei in the dorsal striatum of the mice, and motor activity was promoted. It also increased the extracellular dopamine level in the dorsal striatum of the mice. These observations indicated that after subcutaneous administration, l-menthol enhances dopamine-mediated neurotransmission, and activates neuronal activity in the dorsal striatum, thereby promoting motor activity in mice.

Published
2021
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2. l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

Author

Tomoharu Sano, Toyoshi Umezu, and Junko Hayashi

Subjects
Male, Physiology, Dopamine, Walking, Striatum, Synaptic Transmission, Biochemistry, c-Fos, Nucleus Accumbens, Mice, chemistry.chemical_compound, Catecholamines, Animal Cells, Arcuate Nucleus, Medicine and Health Sciences, Premovement neuronal activity, Amines, Neurotransmitter, Neurons, Mice, Inbred ICR, Multidisciplinary, Behavior, Animal, biology, Organic Compounds, Chemistry, Brain, Neurochemistry, Neurotransmitters, Menthol, medicine.anatomical_structure, Physical Sciences, Medicine, Anatomy, Cellular Types, Proto-Oncogene Proteins c-fos, Research Article, medicine.drug, Biogenic Amines, medicine.medical_specialty, Science, Central nervous system, Hypothalamus, Motor Activity, Neurotransmission, Internal medicine, medicine, Animals, Dopamine Transporters, Cell Nucleus, Biological Locomotion, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Cell Biology, Corpus Striatum, Hormones, Neostriatum, Endocrinology, Cellular Neuroscience, biology.protein, Neuroscience
Abstract

Similar to psychostimulants, the peripheral administration of menthol promotes mouse motor activity, and the neurotransmitter dopamine has been suggested to be involved in this effect. The present study aimed to elucidate the effects of l-menthol on parts of the central nervous system that are involved in motor effects. The subcutaneous administration of l-menthol significantly increased the number of c-Fos-like immunoreactive nuclei in the dorsal striatum of the mice, and motor activity was promoted. It also increased the extracellular dopamine level in the dorsal striatum of the mice. These observations indicated that after subcutaneous administration, l-menthol enhances dopamine-mediated neurotransmission, and activates neuronal activity in the dorsal striatum, thereby promoting motor activity in mice.

Published
2021

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