Search

Your search keyword '"Susann Friedel"' showing total 2 results
Start Over Author "Susann Friedel" Publisher public library of science (plos)
2 results on '"Susann Friedel"'

1. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants.

Author

Anke Hinney, Thuy Trang Nguyen, André Scherag, Susann Friedel, Günter Brönner, Timo Dirk Müller, Harald Grallert, Thomas Illig, H-Erich Wichmann, Winfried Rief, Helmut Schäfer, and Johannes Hebebrand

Subjects
Medicine, Science
Abstract

Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity.a) GWA (Genome-Wide Human SNP Array 5.0 comprising 440,794 single nucleotide polymorphisms) for early onset extreme obesity based on 487 extremely obese young German individuals and 442 healthy lean German controls; b) confirmatory analyses on 644 independent families with at least one obese offspring and both parents. We aimed to identify and subsequently confirm the 15 SNPs (minor allele frequency > or =10%) with the lowest p-values of the GWA by four genetic models: additive, recessive, dominant and allelic. Six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) within one linkage disequilibrium (LD) block including the GWA SNP rendering the lowest p-value (rs1121980; log-additive model: nominal p = 1.13 x 10(-7), corrected p = 0.0494; odds ratio (OR)(CT) 1.67, 95% confidence interval (CI) 1.22-2.27; OR(TT) 2.76, 95% CI 1.88-4.03) belonged to the 15 SNPs showing the strongest evidence for association with obesity. For confirmation we genotyped 11 of these in the 644 independent families (of the six FTO SNPs we chose only two representing the LD bock). For both FTO SNPs the initial association was confirmed (both Bonferroni corrected p

Published
2007
Full Text
View/download PDF

2. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants

Author

Timo D. Müller, Thuy Trang Nguyen, H.-Erich Wichmann, André Scherag, Thomas Illig, Günter Brönner, Winfried Rief, Susann Friedel, Anke Hinney, Harald Grallert, Johannes Hebebrand, and Helmut Schäfer

Subjects
Linkage disequilibrium, Adolescent, Medizin, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, lcsh:Medicine, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Genome-wide association study, Biology, Genetics and Genomics/Complex Traits, Bioinformatics, FTO gene, Polymorphism, Single Nucleotide, Childhood obesity, Diabetes and Endocrinology/Obesity, 03 medical and health sciences, 0302 clinical medicine, Genetic model, medicine, Humans, Diabetes and Endocrinology/Type 2 Diabetes, Obesity, Child, lcsh:Science, Genetics and Genomics/Genetics of Disease, 030304 developmental biology, 2. Zero hunger, Genetics, Genetics and Genomics/Medical Genetics, 0303 health sciences, Multidisciplinary, Genome, Human, lcsh:R, Proteins, Genetics and Genomics, Organ Size, medicine.disease, 3. Good health, Minor allele frequency, Adipose Tissue, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Genetics and Genomics/Gene Discovery, lcsh:Q, SNP array, Research Article
Abstract

Background. Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity. Methodology/Principal Findings. a) GWA (Genome-Wide Human SNP Array 5.0 comprising 440,794 single nucleotide polymorphisms) for early onset extreme obesity based on 487 extremely obese young German individuals and 442 healthy lean German controls; b) confirmatory analyses on 644 independent families with at least one obese offspring and both parents. We aimed to identify and subsequently confirm the 15 SNPs (minor allele frequency ≥ 10%) with the lowest p-values of the GWA by four genetic models: additive, recessive, dominant and allelic. Six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) within one linkage disequilibrium (LD) block including the GWA SNP rendering the lowest p-value (rs1121980; log-additive model: nominal p=1.13×10⁻⁷, corrected p=0.0494; odds ratio (OR)CT 1.67, 95% confidence interval (Cl) 1.22-2.27; ORTT 2.76, 95% Cl 1.88-4.03) belonged to the 15 SNPs showing the strongest evidence for association with obesity. For confirmation we genotyped 11 of these in the 644 independent families (of the six FTO SNPs we chose only two representing the LD bock). For both FTO SNPs the initial association was confirmed (both Bonferroni corrected p

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results