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Your search keyword '"Roland F. Hoffmann"' showing total 1 results
Start Over Author "Roland F. Hoffmann" Publisher public library of science (plos)
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1. Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress.

Author

Marike W van Gisbergen, An M Voets, Rianne Biemans, Roland F Hoffmann, Marie-José Drittij-Reijnders, Guido R M M Haenen, Irene H Heijink, Kasper M A Rouschop, Ludwig J Dubois, and Philippe Lambin

Subjects
Medicine, Science
Abstract

Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content, attributed to altered reactive oxygen species (ROS) production and antioxidant capacity. For this purpose BEAS-2B, A549, and 143B cell lines were depleted from their mtDNA (ρ0). Overall survival after irradiation was increased (p

Published
2017
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