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Your search keyword '"Rajil Mehta"' showing total 2 results
Start Over Author "Rajil Mehta" Publisher public library of science (plos)
2 results on '"Rajil Mehta"'

1. Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury-A retrospective cohort study.

Author

Cheol Woong Jung, Dana Jorgensen, Puneet Sood, Rajil Mehta, Michele Molinari, Sundaram Hariharan, Armando Ganoza, Dirk Van Der Windt, Martin N Wijkstrom, Chethan M Puttarajappa, and Amit D Tevar

Subjects
Medicine, Science
Abstract

Due to shortage of donor, kidney transplants (KTs) from donors with acute kidney injury (AKI) are expanding. Although previous studies comparing clinical outcomes between AKI and non-AKI donors in KTs have shown comparable results, data on high-volume analysis of KTs outcomes with AKI donors are limited. This study aimed to analyze the selection trends of AKI donors and investigate the impact of AKI on graft failure using the United states cohort data. We analyzed a total 52,757 KTs collected in the Scientific Registry of Transplant Recipient (SRTR) from 2010 to 2015. The sample included 4,962 (9.4%) cases of KTs with AKI donors (creatinine ≥ 2 mg/dL). Clinical characteristics of AKI and non-AKI donors were analyzed and outcomes of both groups were compared. We also analyzed risk factors for graft failure in AKI donor KTs. Although the incidence of delayed graft function was higher in recipients of AKI donors compared to non-AKI donors, graft and patient survival were not significantly different between the two groups. We found donor hypertension, cold ischemic time, the proportion of African American donors, and high KDPI were risk factors for graft failure in AKI donor KTs. KTs from deceased donor with AKI showed comparable outcomes. Thus, donors with AKI need to be considered more actively to expand donor pool. Caution is still needed when donors have additional risk factors of graft failure.

Published
2021
Full Text
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2. Outcomes and factors leading to graft failure in kidney transplants from deceased donors with acute kidney injury—A retrospective cohort study

Author

Dana R. Jorgensen, Michele Molinari, Chethan Puttarajappa, Sundaram Hariharan, Amit D. Tevar, Cheol Woong Jung, Martin Wijkstrom, Dirk J. van der Windt, Armando Ganoza, Puneet Sood, and Rajil Mehta

Subjects
Graft Rejection, Male, Epidemiology, urologic and male genital diseases, Biochemistry, chemistry.chemical_compound, Endocrinology, Medical Conditions, Chronic Kidney Disease, Medicine and Health Sciences, Renal Transplantation, Ethnicities, Registries, African American people, Kidney, Multidisciplinary, Incidence (epidemiology), Graft Survival, Acute kidney injury, Population groupings, Acute Kidney Injury, female genital diseases and pregnancy complications, Delayed Graft Function, medicine.anatomical_structure, Nephrology, Creatinine, Cohort, Medicine, Female, Anatomy, Research Article, Adult, medicine.medical_specialty, Graft failure, Endocrine Disorders, Science, Surgical and Invasive Medical Procedures, Urinary System Procedures, Donor Selection, Internal medicine, Diabetes Mellitus, Renal Diseases, medicine, Humans, Retrospective Studies, Transplantation, Risk Management, urogenital system, business.industry, Biology and Life Sciences, Kidneys, Retrospective cohort study, Renal System, Organ Transplantation, medicine.disease, Kidney Transplantation, chemistry, Medical Risk Factors, Metabolic Disorders, People and places, business, Biomarkers
Abstract

Due to shortage of donor, kidney transplants (KTs) from donors with acute kidney injury (AKI) are expanding. Although previous studies comparing clinical outcomes between AKI and non-AKI donors in KTs have shown comparable results, data on high-volume analysis of KTs outcomes with AKI donors are limited. This study aimed to analyze the selection trends of AKI donors and investigate the impact of AKI on graft failure using the United states cohort data. We analyzed a total 52,757 KTs collected in the Scientific Registry of Transplant Recipient (SRTR) from 2010 to 2015. The sample included 4,962 (9.4%) cases of KTs with AKI donors (creatinine ≥ 2 mg/dL). Clinical characteristics of AKI and non-AKI donors were analyzed and outcomes of both groups were compared. We also analyzed risk factors for graft failure in AKI donor KTs. Although the incidence of delayed graft function was higher in recipients of AKI donors compared to non-AKI donors, graft and patient survival were not significantly different between the two groups. We found donor hypertension, cold ischemic time, the proportion of African American donors, and high KDPI were risk factors for graft failure in AKI donor KTs. KTs from deceased donor with AKI showed comparable outcomes. Thus, donors with AKI need to be considered more actively to expand donor pool. Caution is still needed when donors have additional risk factors of graft failure.

Published
2021
Full Text
View/download PDF

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