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Your search keyword '"Nausch, Norman"' showing total 18 results
Start Over Author "Nausch, Norman" Publisher public library of science (plos)
18 results on '"Nausch, Norman"'

2. Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses

Author

Ritter, Manuel, primary, Ndongmo, Winston Patrick Chounna, additional, Njouendou, Abdel Jelil, additional, Nghochuzie, Nora Nganyewo, additional, Nchang, Lucy Cho, additional, Tayong, Dizzle Bita, additional, Arndts, Kathrin, additional, Nausch, Norman, additional, Jacobsen, Marc, additional, Wanji, Samuel, additional, Layland, Laura E., additional, and Hoerauf, Achim, additional

Published
2018
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3. Aberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis

Author

Lundtoft, Christian, primary, Afum-Adjei Awuah, Anthony, additional, Rimpler, Jens, additional, Harling, Kirstin, additional, Nausch, Norman, additional, Kohns, Malte, additional, Adankwah, Ernest, additional, Lang, Franziska, additional, Olbrich, Laura, additional, Mayatepek, Ertan, additional, Owusu-Dabo, Ellis, additional, and Jacobsen, Marc, additional

Published
2017
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4. Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression

Author

Nausch, Norman, primary, Antwi-Berko, Daniel, additional, Mubarik, Yusif, additional, Abass, Kabiru Mohammed, additional, Owusu, Wellington, additional, Owusu-Dabo, Ellis, additional, Debrah, Linda Batsa, additional, Debrah, Alexander Yaw, additional, Jacobsen, Marc, additional, and Phillips, Richard O., additional

Published
2017
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6. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection

Author

Hoy, Anna M., Lundie, Rachel J., Ivens, Alasdair, Quintana, Juan F., Nausch, Norman, Forster, Thorsten, Jones, Frances, Kabatereine, Narcis B., Dunne, David W., Mutapi, Francisca, MacDonald, Andrew S., Buck, Amy H., Dunne, David [0000-0002-8940-9886], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, Mice, Young Adult, Diagnostic Medicine, Pathology, Parasitic Diseases, Animals, Humans, Child, lcsh:Public aspects of medicine, lcsh:RA1-1270, Schistosoma mansoni, Middle Aged, Schistosomiasis mansoni, Mice, Inbred C57BL, MicroRNAs, Infectious Diseases, Liver, Child, Preschool, Medicine, Female, RNA, Helminth, Biomarkers, Research Article, General Pathology
Abstract

Background MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection. Methods/Principal Findings We used Exiqon miRNA microarrays to profile miRNA expression in the livers of mice infected with S. mansoni at 7 weeks post-infection. Thirty-three mouse miRNAs were differentially expressed in infected compared to naïve mice (>2 fold change, p, Author Summary Schistosomiasis is a chronic disease caused by blood flukes that affects over 200 million people worldwide, of which 90% live in Sub-Saharan Africa. In the field setting schistosomiasis caused by S. mansoni is diagnosed by detection of parasite eggs in stool samples using microscopic techniques. Here we investigate the potential of microRNAs (miRNAs), a class of short noncoding RNAs, to act as biomarkers of S. mansoni infection. We have identified a specific subset of murine miRNAs whose expression is significantly altered in the liver between 6–12 weeks post infection. However their abundance in serum is not significantly different between naïve and S. mansoni-infected mice until twelve weeks post infection and they do not display consistent differential abundance in the serum of infected versus uninfected humans. In contrast, three parasite-derived miRNAs (miR-277, bantam and miR-3479-3p) were detected in the serum of infected mice and human patients and the combined detection of these miRNAs could distinguish S. mansoni infected from uninfected individuals from low and high infection intensity areas with 89%/80% or 80%/90% specificity/sensitivity, respectively. These results demonstrate that miRNAs of parasite origin are a new class of serum biomarker for detecting S. mansoni and likely other helminth infections.

Published
2014

13. Age-Related Patterns in Human Myeloid Dendritic Cell Populations in People Exposed to Schistosoma haematobium Infection

Author

Nausch, Norman, primary, Louis, Delphine, additional, Lantz, Olivier, additional, Peguillet, Isabelle, additional, Trottein, François, additional, Chen, Isobel Y. D., additional, Appleby, Laura J., additional, Bourke, Claire D., additional, Midzi, Nicholas, additional, Mduluza, Takafira, additional, and Mutapi, Francisca, additional

Published
2012
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18. Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection

Author

Hoy, Anna M, Lundie, Rachel J, Ivens, Alasdair, Quintana, Juan F, Nausch, Norman, Forster, Thorsten, Jones, Frances, Kabatereine, Narcis B, Dunne, David W, Mutapi, Francisca, Macdonald, Andrew S, and Buck, Amy H

Subjects
Adult, Male, Adolescent, Schistosoma mansoni, Middle Aged, Schistosomiasis mansoni, 3. Good health, Mice, Inbred C57BL, Mice, MicroRNAs, Young Adult, Liver, Child, Preschool, Animals, Humans, Female, RNA, Helminth, Child, Biomarkers
Abstract

BACKGROUND: MicroRNAs (miRNAs) are a class of short non-coding RNA that play important roles in disease processes in animals and are present in a highly stable cell-free form in body fluids. Here, we examine the capacity of host and parasite miRNAs to serve as tissue or serum biomarkers of Schistosoma mansoni infection. METHODS/PRINCIPAL FINDINGS: We used Exiqon miRNA microarrays to profile miRNA expression in the livers of mice infected with S. mansoni at 7 weeks post-infection. Thirty-three mouse miRNAs were differentially expressed in infected compared to naïve mice (>2 fold change, p

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