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Your search keyword '"Marcos Vinicius da Silva Pone"' showing total 2 results
Start Over Author "Marcos Vinicius da Silva Pone" Publisher public library of science (plos)
2 results on '"Marcos Vinicius da Silva Pone"'

1. Neurodevelopment of children exposed intra-uterus by Zika virus: A case series.

Author

Pedro Massaroni Peçanha, Saint Clair Gomes Junior, Sheila Moura Pone, Marcos Vinicius da Silva Pone, Zilton Vasconcelos, Andrea Zin, Renata Hydee Hasue Vilibor, Roozemeria Pereira Costa, Maria Dalva Barbosa Baker Meio, Karin Nielsen-Saines, Patricia Brasil, Elizabeth Brickley, and Maria Elisabeth Lopes Moreira

Subjects
Medicine, Science
Abstract

The main goal of this manuscript was to investigate the neurodevelopment of children exposed by Zika virus in the intrauterine period who are asymptomatic at birth. Newborns with documented Zika virus exposure during the intrauterine period who were asymptomatic at birth were followed in the first two years of life for neurodevelopment using Bayley III test. Children were classified as having normal or delayed neurodevelopment for age based on most recent Bayley III evaluation results. Eighty-four infants were included in the study. The first Bayley III evaluation was performed at a mean chronological age of 9.7±3.1 month; 13 children (15%) had a delay in one of the three domains, distributed as follow: 10 (12%) in the language domain and 3 (3.5%) in the motor domain. The most recent Bayley III evaluation was performed at a mean age 15.3±3.1 months; 42 children (50%) had a delay in one of the three domains: 4 (5%) in cognition, 31 (37%) in language, and 20 (24%) in motor performance. There were no statistical differences in Gender, Gestational Age, Birth Weight and Head Circurference at birth between children with normal and delayed neurodevelopment for age. A very high proportion of children exposed ZIKV during pregnancy who were asymptomatic at birth demonstrated a delay in neurodevelopment, mainly in the language domain, the first two years of life.

Published
2020
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2. Cardiac findings in infants with in utero exposure to Zika virus- a cross sectional study

Author

Maria de Fatima Monteiro Pereira Leite, Maria Elizabeth Lopes Moreira, Sheila Moura Pone, Marcos Vinicius da Silva Pone, Karin Nielsen-Saines, Sonia Regina Lambert Passos, Helena A. R. Teixeira Mendes, Raquel de Vasconcellos Carvalhaes de Oliveira, Carla Verona Barreto Farias, and Dulce Helena Gonçalves Orofino

Subjects
RNA viruses, Central Nervous System, Male, Pediatrics, Cross-sectional study, Maternal Health, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Nervous System, Polymerase Chain Reaction, Geographical locations, Zika virus, Families, 0302 clinical medicine, Pregnancy, Ductus arteriosus, Medicine and Health Sciences, Morphogenesis, Medicine, Pregnancy Complications, Infectious, Children, education.field_of_study, biology, Zika Virus Infection, lcsh:Public aspects of medicine, Incidence (epidemiology), Obstetrics and Gynecology, Heart, Congenital Heart Defects, Infectious Diseases, medicine.anatomical_structure, Medical Microbiology, Echocardiography, In utero, Viral Pathogens, Viruses, Female, Pathogens, Anatomy, Infants, Brazil, Research Article, Heart Defects, Congenital, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, Population, Cardiology, Mothers, Microbiology, 03 medical and health sciences, Fetus, Congenital Disorders, Humans, Birth Defects, education, Microbial Pathogens, Newborn screening, Biology and life sciences, Flaviviruses, business.industry, Organisms, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, lcsh:RA1-1270, Zika Virus, South America, Amniotic Fluid, biology.organism_classification, medicine.disease, Infectious Disease Transmission, Vertical, Cross-Sectional Studies, Age Groups, People and Places, Ventricular Septal Defects, Cardiovascular Anatomy, Women's Health, Population Groupings, business, Developmental Biology
Abstract

Background Antenatal exposure to Zika virus (ZIKV) is related to severe neurological manifestations. A previous study in Brazil reported an increased incidence of non-severe congenital heart defects in infants with diagnosis of congenital Zika syndrome but without laboratory confirmation of ZIKV infection in the mother or infant. The objective of this study is to report echocardiographic (ECHO) findings in infants with laboratory confirmed antenatal exposure to ZIKV. Methodology Cross sectional study of cardiologic assessments of infants born between November 2015 and January 2017 with confirmed vertical exposure to ZIKV in Rio de Janeiro, Brazil. Results The study enrolled 120 children with a median age of 97 days (1 to 376 days). In utero exposure to ZIKV was confirmed in 97 children (80,8%) through positive maternal polymerase chain reaction (PCR) results during pregnancy or a positive PCR result at birth; 23 additional children (19.2%) had maternal positive PCR results during pregnancy and postnatally. Forty- eight infants (40%) had cardiac defects noted on ECHO. Thirteen infants (10.8%) had major cardiac defects (atrial septal defect, ventricular septal defect, patent ductus arteriosus). None of the defects were severe. The frequency of major defects was higher in infants whose mothers had a rash in the 2nd trimester of pregnancy, or who had altered Central Nervous System (CNS) imaging postnatally or were preterm. Conclusions Infants with in utero ZIKV exposure have a higher prevalence of major cardiac defects, however none were severe enough to require immediate intervention. For this reason, guidelines for performance of postnatal ECHO in this population should follow general newborn screening guidelines, which significantly reduces the burden of performing emergent fetal or neonatal ECHOs in a setting where resources are not available, such as most Brazilian municipalities., Author summary We performed cardiologic assessment of 120 infants born between November 2015 and January 2017 with confirmed vertical exposure to Zika virus (ZIKV). The diagnosis of ZIKV exposure was confirmed by PCR in maternal blood specimens and/or amniotic fluid during pregnancy and/or infant specimens including PCR of the cerebrospinal fluid (CSF) and/or urine following birth. Our study found a 10.8% incidence of structural heart defects in infants with a history of intrauterine exposure to ZIKV, a rate considerably higher than that observed in the general population. However, no patients were found to have severe structural heart defects. The presence of major defects was increased in infants whose mothers had a history of rash in the 2nd trimester, infants with altered CNS imaging and/or preterm infants. As severe heart defects requiring immediate intervention were not identified, guidelines for performance of postnatal ECHO in this population should follow the same criteria as the ones applicable to newborns in general, particularly since resources for performance of fetal and neonatal echocardiograms are not routinely available in most Brazilian municipalities

Published
2018
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