1. A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion
- Author
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Vijay Sharma, Nigam P. Rath, Jothilingam Sivapackiam, Hannah Gu, David Piwnica-Worms, Scott E. Harpstrite, and Julie L. Prior
- Subjects
Male ,Science ,Cardiology ,chemistry.chemical_element ,Gallium Radioisotopes ,Cell Line ,Diagnostic Radiology ,Rats, Sprague-Dawley ,Myocardial perfusion imaging ,Mice ,Diagnostic Medicine ,medicine ,Organometallic Compounds ,Medicine and Health Sciences ,Animals ,Humans ,Gallium ,Cardiovascular Imaging ,Radionuclide Imaging ,Multidisciplinary ,medicine.diagnostic_test ,Chemistry ,business.industry ,Radionuclide Generators ,Radiology and Imaging ,Myocardial Perfusion Imaging ,Pet imaging ,Ethylenediamines ,Rats ,Sprague dawley ,Positron emission tomography ,Positron-Emission Tomography ,MCF-7 Cells ,Medicine ,Radionuclide Generator ,Radiopharmaceuticals ,Nuclear medicine ,business ,Perfusion ,Preclinical imaging ,Biomedical engineering ,Research Article - Abstract
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
- Published
- 2014