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Start Over Author "Jochen Hammes" Publisher public library of science (plos)
2 results on '"Jochen Hammes"'

1. Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT.

Author

Jochen Hammes, Melanie Hohberg, Philipp Täger, Markus Wild, Boris Zlatopolskiy, Philipp Krapf, Bernd Neumaier, Klaus Schomäcker, Carsten Kobe, Matthias Schmidt, Markus Dietlein, and Alexander Drzezga

Subjects
Medicine, Science
Abstract

INTRODUCTION:[68Ga]PSMA-HBED-CC and [18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal. METHODS:A comparison of average bone SUV was performed in 17 bone-negative and 4 bone-positive patients. All patients underwent PET/CT 125 minutes after application of [18F]DCFPyL and 73 minutes after application of [68Ga]PSMA-HBED-CC at another date. RESULTS:Native SUVs in unaffected bone tissue and SUVs relative to liver uptake were lower in [18F]DCFPyL (0.49) than in [68Ga]PSMA-HBED-CC scans (0.52). SUVs relative to gluteal muscles did not differ between the two tracers. Average lesional SUVs did not differ between tracers. CONCLUSION:No difference of average bone signal intensity was observed for [18F]DCFPyL-PET/CT in comparison to [68Ga]PSMA-HBED-CC scans indicating that diagnostic assessment of the skeleton is not affected by non-specific accumulation of free [18F]fluoride or 68Ga.

Published
2018
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2. Uptake in non-affected bone tissue does not differ between [18F]-DCFPyL and [68Ga]-HBED-CC PSMA PET/CT

Author

Matthias Schmidt, Melanie Hohberg, Philipp Täger, Boris D. Zlatopolskiy, Carsten Kobe, Bernd Neumaier, Alexander Drzezga, Markus Dietlein, Klaus Schomäcker, Markus Wild, Jochen Hammes, and Philipp Krapf

Subjects
Glutamate Carboxypeptidase II, Male, Bone tissue, Biochemistry, Salivary Glands, Diagnostic Radiology, Metastasis, 030218 nuclear medicine & medical imaging, Prostate cancer, 0302 clinical medicine, Basic Cancer Research, Medicine and Health Sciences, Neoplasm Metastasis, Tomography, Musculoskeletal System, Multidisciplinary, medicine.diagnostic_test, Chemistry, Radiology and Imaging, Prostate Cancer, Applied Mathematics, Simulation and Modeling, Prostate Diseases, Skeleton (computer programming), Blood proteins, Bone Imaging, 68Ga-HBED-CC-PSMA, medicine.anatomical_structure, Oncology, Positron emission tomography, 030220 oncology & carcinogenesis, Physical Sciences, Antigens, Surface, Medicine, Anatomy, Algorithms, Research Article, Imaging Techniques, Science, Urology, Neuroimaging, Gallium Radioisotopes, Research and Analysis Methods, Bone and Bones, 03 medical and health sciences, Exocrine Glands, Diagnostic Medicine, medicine, Humans, ddc:610, Skeleton, Aged, PET-CT, Plasma Proteins, business.industry, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Prostatic Neoplasms, medicine.disease, Genitourinary Tract Tumors, Positron-Emission Tomography, Neoplasm Recurrence, Local, Radiopharmaceuticals, Nuclear medicine, business, Digestive System, Positron Emission Tomography, Mathematics, Neuroscience
Abstract

Introduction [68Ga]PSMA-HBED-CC and [18F]DCFPyL show a high potential for the detection of recurrent prostate cancer. While 18F-based tracers have several advantages in availability and image resolution, their sensitivity in the skeleton might be impaired by released [18F]fluoride due to its high bone affinity. In turn, chemically unbound trivalent 68Ga might also accumulate in osseous tissue, in cases of occupied binding sites of plasma proteins and thereby influence bone signal. Methods A comparison of average bone SUV was performed in 17 bone-negative and 4 bone-positive patients. All patients underwent PET/CT 125 minutes after application of [18F]DCFPyL and 73 minutes after application of [68Ga]PSMA-HBED-CC at another date. Results Native SUVs in unaffected bone tissue and SUVs relative to liver uptake were lower in [18F]DCFPyL (0.49) than in [68Ga]PSMA-HBED-CC scans (0.52). SUVs relative to gluteal muscles did not differ between the two tracers. Average lesional SUVs did not differ between tracers. Conclusion No difference of average bone signal intensity was observed for [18F]DCFPyL-PET/CT in comparison to [68Ga]PSMA-HBED-CC scans indicating that diagnostic assessment of the skeleton is not affected by non-specific accumulation of free [18F]fluoride or 68Ga.

Published
2018
Full Text
View/download PDF

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