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Your search keyword '"Jaime, Algorta"' showing total 2 results
Start Over Author "Jaime, Algorta" Publisher public library of science (plos)
2 results on '"Jaime, Algorta"'

1. The expanded mtDNA phylogeny of the Franco-Cantabrian region upholds the pre-neolithic genetic substrate of Basques.

Author

Sergio Cardoso, Laura Valverde, Miguel A Alfonso-Sánchez, Leire Palencia-Madrid, Xabier Elcoroaristizabal, Jaime Algorta, Susana Catarino, David Arteta, Rene J Herrera, María Teresa Zarrabeitia, José A Peña, and Marian M de Pancorbo

Subjects
Medicine, Science
Abstract

The European genetic landscape has been shaped by several human migrations occurred since Paleolithic times. The accumulation of archaeological records and the concordance of different lines of genetic evidence during the last two decades have triggered an interesting debate concerning the role of ancient settlers from the Franco-Cantabrian region in the postglacial resettlement of Europe. Among the Franco-Cantabrian populations, Basques are regarded as one of the oldest and more intriguing human groups of Europe. Recent data on complete mitochondrial DNA genomes focused on macrohaplogroup R0 revealed that Basques harbor some autochthonous lineages, suggesting a genetic continuity since pre-Neolithic times. However, excluding haplogroup H, the most representative lineage of macrohaplogroup R0, the majority of maternal lineages of this area remains virtually unexplored, so that further refinement of the mtDNA phylogeny based on analyses at the highest level of resolution is crucial for a better understanding of the European prehistory. We thus explored the maternal ancestry of 548 autochthonous individuals from various Franco-Cantabrian populations and sequenced 76 mitogenomes of the most representative lineages. Interestingly, we identified three mtDNA haplogroups, U5b1f, J1c5c1 and V22, that proved to be representative of Franco-Cantabria, notably of the Basque population. The seclusion and diversity of these female genetic lineages support a local origin in the Franco-Cantabrian area during the Mesolithic of southwestern Europe, ~10,000 years before present (YBP), with signals of expansions at ~3,500 YBP. These findings provide robust evidence of a partial genetic continuity between contemporary autochthonous populations from the Franco-Cantabrian region, specifically the Basques, and Paleolithic/Mesolithic hunter-gatherer groups. Furthermore, our results raise the current proportion (≈ 15%) of the Franco-Cantabrian maternal gene pool with a putative pre-Neolithic origin to ≈ 35%, further supporting the notion of a predominant Paleolithic genetic substrate in extant European populations.

Published
2013
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2. White blood cell counts as risk markers of developing metabolic syndrome and its components in the Predimed study

Author

Jaime Algorta, Marta Guasch-Ferré, Itziar Salaverría Lete, Josep Basora, Mònica Bulló, Rosa Casas, Estefania Toledo, Miguel A. Martinez-Gonzalez, ITZIAR ZAZPE, Julia Warnberg, Andrés Díaz-López, Francisco M Martín Luján, José V Sorlí, José Manuel Santos Lozano, Lluis Serra-Majem, Jordi Salas-Salvadó, NANCY BABIO SÁNCHEZ, Manuel Ortega-Calvo, Inmaculada Bautista-Castaño, Almudena Sanchez Villegas, Joan D. Fernandez-Ballart, PREDIMER Study Investigators, [Babio,N, Ibarrola-Jurado,N, Bulló,M, Salas-Salvadó,J] Human Nutrition Unit, Sant Joan Hospital, IISPV, Universitat Rovira i Virgili, Reus, Spain. [Babio,N, Ortega-Calvo,M, Estruch,R, Salas-Salvadó,J] CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Reus, Spain. [Martínez-González,MA] Department of Preventive Medicine and Public Health, Medical School-Clínica, University of Navarra, Pamplona, Spain. [Wärnberg,J] Department of Preventive Medicine, University of Málaga, Málaga, Spain. [Salaverría,I] Department of Cardiology, University Hospital Txagorritxu, Vitoria, Spain. Department of Family Medicine, Primary Care Division of Sevilla, Esperanza Macarena Health Center, Sevilla, Spain. [Estruch,R] Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Serra-Majem,LL] Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain. [Covas,MI] Cardiovascular Epidemiology Unit, Municipal Institute for Medical Research (IMIM), Barcelona, Spain. [Sorli,JV] Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain. CIBER Fisiopatología de la Obesidad y Nutricion, Valencia, Spain., This study was funded, in part, by the Spanish Ministry of Health (ISCIII), PI1001407, Thematic Network G03/140, RD06/0045, FEDER (Fondo Europeo de Desarrollo Regional), and the Centre Català de la Nutrició de l'Institut d'Estudis Catalans. None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. CIBERobn is an initiative of ISCIII, Spain., Bioquímica i Biotecnologia, Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili., and Universitat de Barcelona

Subjects
Male, Síndrome metabòlica, Mediterranean diet, Neutrophils, Epidemiology, Estudios transversales, Metabolic disorders, Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Disease, Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Diet, Mediterranean, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Leukocyte Count, Lymphocites, Risk Factors, Blood plasma, Pathology, Medicine, Prospective Studies, Prospective cohort study, Aged, 80 and over, Metabolic Syndrome, Clinical Chemistry, Multidisciplinary, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean [Medical Subject Headings], Middle Aged, Metabolic syndrome, Clinical Laboratory Sciences, 1932-6203, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], medicine.anatomical_structure, Cholesterol, Cardiovascular diseases, Cardiovascular Diseases, White blood cells, Female, Public Health, Enfermedades cardiovasculares, Research Article, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Recuento de linfocitos, Science, Check Tags::Male [Medical Subject Headings], Mediterranean cooking, Diagnostic Medicine, Internal medicine, White blood cell, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count::Lymphocyte Count [Medical Subject Headings], Cuina mediterrània, Humans, Lymphocyte Count, Obesity, Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Diseases::Cardiovascular Diseases [Medical Subject Headings], Cardiovascular Disease Epidemiology, Aged, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X [Medical Subject Headings], business.industry, Malalties cardiovasculars, Recuento de leucocitos, Síndrome X metabólico, medicine.disease, Long-Term Care, Dieta mediterránea, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Leukocyte Count [Medical Subject Headings], Biomarker Epidemiology, Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Geriatrics, Immunology, Clinical Immunology, Preventive Medicine, Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils [Medical Subject Headings], business, Dyslipidemia, Biomarkers, General Pathology
Abstract

Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; TRIAL REGISTRATION Controlled-Trials.comISRCTN35739639. BACKGROUND The Metabolic Syndrome (MetS) is a cluster of metabolic abnormalities that includes hyperglucemia, hypertension, dyslipidemia and central obesity, conferring an increased risk of cardiovascular disease. The white blood cell (WBC) count has been proposed as a marker for predicting cardiovascular risk. However, few prospective studies have evaluated the relationship between WBC subtypes and risk of MetS. METHODS Participants were recruited from seven PREDIMED study centers. Both a baseline cross-sectional (n = 4,377) and a prospective assessment (n = 1,637) were performed. Participants with MetS at baseline were excluded from the longitudinal analysis. The median follow-up was 3.9 years. Anthropometric measurements, blood pressure, fasting glucose, lipid profile and WBC counts were assessed at baseline and yearly during the follow-up. Participants were categorized by baseline WBC and its subtype count quartiles. Adjusted logistic regression models were fitted to assess the risk of MetS and its components. RESULTS Of the 4,377 participants, 62.6% had MetS at baseline. Compared to the participants in the lowest baseline sex-adjusted quartile of WBC counts, those in the upper quartile showed an increased risk of having MetS (OR, 2.47; 95%CI, 2.03-2.99; P-trend

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