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1. Maternal pre-pregnancy weight status modifies the influence of PUFAs and inflammatory biomarkers in breastmilk on infant growth.

Author

Henry Nuss, Abby Altazan, Jovanny Zabaleta, Melinda Sothern, and Leanne Redman

Subjects
Medicine, Science
Abstract

BackgroundHuman breastmilk contains pro- and anti-inflammatory compounds and hormones that can influence infant growth. However, little is known about the specific interrelationships between these compounds and whether their effects on infant growth may be influenced by pre-pregnancy weight status.ObjectiveThe purpose of this novel, prospective cohort study was to assess the interrelationships between pro-inflammatory cytokines (TNF-α, IL-6), hormones (insulin, leptin) and PUFAs (n-6, n-3) in blood and breastmilk in early postpartum between women with normal BMI (Group 1, n = 18; 18.5MethodsParticipants were robustly phenotyped along with their infants at 4-8 weeks postpartum. TNF-α, IL-6, insulin, leptin, and n-3 and n-6 PUFAs measured in blood and breastmilk and compared between pre-pregnancy BMI groups and with infant weight, length, head circumference and % fat mass.ResultsGroup 1 women had higher serum leptin (pConclusionsPro-inflammatory qualities of breastmilk were associated with infant growth measures regardless of maternal pre-pregnancy BMI. However, infants born to women with overweight or obesity demonstrated less responsive growth to breastmilk contents. More studies are needed to assess longitudinal effects of this impact.

Published
2019
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2. Maternal pre-pregnancy weight status modifies the influence of PUFAs and inflammatory biomarkers in breastmilk on infant growth

Author

Jovanny Zabaleta, Henry Nuss, Melinda S. Sothern, Abby D. Altazan, and Leanne M. Redman

Subjects
Male, Leptin, Physiology, Peptide Hormones, Pilot Projects, Overweight, Pathology and Laboratory Medicine, Biochemistry, Body Mass Index, Fats, Families, 0302 clinical medicine, Child Development, Endocrinology, Pregnancy, Immune Physiology, Medicine and Health Sciences, Medicine, Birth Weight, Insulin, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Children, Immune Response, Innate Immune System, Multidisciplinary, Lipids, Physiological Parameters, Fatty Acids, Unsaturated, Cytokines, Female, medicine.symptom, Inflammation Mediators, Infants, Research Article, Adult, Adolescent, Birth weight, Science, Immunology, 030209 endocrinology & metabolism, 03 medical and health sciences, Young Adult, Signs and Symptoms, Diagnostic Medicine, Humans, Obesity, Inflammation, Diabetic Endocrinology, Milk, Human, business.industry, Body Weight, Infant, Newborn, Infant, Biology and Life Sciences, Molecular Development, medicine.disease, Hormones, Age Groups, Immune System, People and Places, Population Groupings, business, Body mass index, Biomarkers, Hormone, Developmental Biology
Abstract

BackgroundHuman breastmilk contains pro- and anti-inflammatory compounds and hormones that can influence infant growth. However, little is known about the specific interrelationships between these compounds and whether their effects on infant growth may be influenced by pre-pregnancy weight status.ObjectiveThe purpose of this novel, prospective cohort study was to assess the interrelationships between pro-inflammatory cytokines (TNF-α, IL-6), hormones (insulin, leptin) and PUFAs (n-6, n-3) in blood and breastmilk in early postpartum between women with normal BMI (Group 1, n = 18; 18.5MethodsParticipants were robustly phenotyped along with their infants at 4-8 weeks postpartum. TNF-α, IL-6, insulin, leptin, and n-3 and n-6 PUFAs measured in blood and breastmilk and compared between pre-pregnancy BMI groups and with infant weight, length, head circumference and % fat mass.ResultsGroup 1 women had higher serum leptin (pConclusionsPro-inflammatory qualities of breastmilk were associated with infant growth measures regardless of maternal pre-pregnancy BMI. However, infants born to women with overweight or obesity demonstrated less responsive growth to breastmilk contents. More studies are needed to assess longitudinal effects of this impact.

Published
2019

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