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Your search keyword '"Cunningham, Adam F"' showing total 14 results
Start Over Author "Cunningham, Adam F" Publisher public library of science (plos)
14 results on '"Cunningham, Adam F"'

2. Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Author

Goodall, Emily C. A., primary, Isom, Georgia L., additional, Rooke, Jessica L., additional, Pullela, Karthik, additional, Icke, Christopher, additional, Yang, Zihao, additional, Boelter, Gabriela, additional, Jones, Alun, additional, Warner, Isabel, additional, Da Costa, Rochelle, additional, Zhang, Bing, additional, Rae, James, additional, Tan, Wee Boon, additional, Winkle, Matthias, additional, Delhaye, Antoine, additional, Heinz, Eva, additional, Collet, Jean-Francois, additional, Cunningham, Adam F., additional, Blaskovich, Mark A., additional, Parton, Robert G., additional, Cole, Jeff A., additional, Banzhaf, Manuel, additional, Chng, Shu-Sin, additional, Vollmer, Waldemar, additional, Bryant, Jack A., additional, and Henderson, Ian R., additional

Published
2021
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3. Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease

Author

Wall, Nadezhda A., primary, Dominguez-Medina, C. Coral, additional, Faustini, Sian E., additional, Cook, Charlotte N., additional, McClean, Andrew, additional, Jesky, Mark D., additional, Perez-Toledo, Marisol, additional, Morgan, Matthew D., additional, Richter, Alexandra G., additional, Ferro, Charles J., additional, Cockwell, Paul, additional, Moss, Paul A., additional, Henderson, Ian R., additional, Harper, Lorraine, additional, and Cunningham, Adam F., additional

Published
2018
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4. Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen

Author

Hart, Peter J, O'Shaughnessy, Colette M, Siggins, Matthew K, Bobat, Saeeda, Kingsley, Robert A, Goulding, David A, Crump, John A, Reyburn, Hugh, Micoli, Francesca, Dougan, Gordon, Cunningham, Adam F, and MacLennan, Calman A

Subjects
Lipopolysaccharides, Salmonella typhimurium, General Science & Technology, Science, Primary Cell Culture, Complement Membrane Attack Complex, Emerging and Re-emerging Infectious Diseases, Phagocytosis, Species Specificity, MD Multidisciplinary, Humans, Typhoid Fever, Bacterial Capsules, Antigens, Bacterial, Phagocytes, Immune Sera, Polysaccharides, Bacterial, Typhoid-Paratyphoid Vaccines, Complement C3, Salmonella typhi, Antibodies, Bacterial, Immunity, Humoral, Salmonella Infections, Medicine, Immunization
Abstract

Salmonella enterica serovar Typhi expresses a capsule of Vi polysaccharide, while most Salmonella serovars, including S. Enteritidis and S. Typhimurium, do not. Both S. Typhi and S. Enteritidis express the lipopolysaccharide O:9 antigen, yet there is little evidence of cross-protection from anti-O:9 antibodies. Vaccines based on Vi polysaccharide have efficacy against typhoid fever, indicating that antibodies against Vi confer protection. Here we investigate the role of Vi capsule and antibodies against Vi and O:9 in antibody-dependent complement- and phagocyte-mediated killing of Salmonella. Using isogenic Vi-expressing and non-Vi-expressing derivatives of S. Typhi and S. Typhimurium, we show that S. Typhi is inherently more sensitive to serum and blood than S. Typhimurium. Vi expression confers increased resistance to both complement- and phagocyte-mediated modalities of antibody-dependent killing in human blood. The Vi capsule is associated with reduced C3 and C5b-9 deposition, and decreased overall antibody binding to S. Typhi. However, purified human anti-Vi antibodies in the presence of complement are able to kill Vi-expressing Salmonella, while killing by anti-O:9 antibodies is inversely related to Vi expression. Human serum depleted of antibodies to antigens other than Vi retains the ability to kill Vi-expressing bacteria. Our findings support a protective role for Vi capsule in preventing complement and phagocyte killing of Salmonella that can be overcome by specific anti-Vi antibodies, but only to a limited extent by anti-O:9 antibodies.

Published
2016

5. Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1

Author

Marini, Arianna, primary, Rossi, Omar, additional, Aruta, Maria Grazia, additional, Micoli, Francesca, additional, Rondini, Simona, additional, Guadagnuolo, Serafina, additional, Delany, Isabel, additional, Henderson, Ian R., additional, Cunningham, Adam F., additional, Saul, Allan, additional, MacLennan, Calman A., additional, and Koeberling, Oliver, additional

Published
2017
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6. The M3 Muscarinic Receptor Is Required for Optimal Adaptive Immunity to Helminth and Bacterial Infection

Author

Darby, Matthew, primary, Schnoeller, Corinna, additional, Vira, Alykhan, additional, Culley, Fiona, additional, Bobat, Saeeda, additional, Logan, Erin, additional, Kirstein, Frank, additional, Wess, Jürgen, additional, Cunningham, Adam F., additional, Brombacher, Frank, additional, Selkirk, Murray E., additional, and Horsnell, William G. C., additional

Published
2015
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7. Natural and Vaccine-Mediated Immunity to Salmonella Typhimurium is Impaired by the Helminth Nippostrongylus brasiliensis

Author

Bobat, Saeeda, primary, Darby, Matthew, additional, Mrdjen, Dunja, additional, Cook, Charlotte, additional, Logan, Erin, additional, Auret, Jennifer, additional, Jones, Elizabeth, additional, Schnoeller, Corinna, additional, Flores-Langarica, Adriana, additional, Ross, Ewan A., additional, Vira, Alykhan, additional, López-Macías, Constantino, additional, Henderson, Ian R., additional, Alexander, James, additional, Brombacher, Frank, additional, Horsnell, William G., additional, and Cunningham, Adam F., additional

Published
2014
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9. Mutational and Topological Analysis of the Escherichia coli BamA Protein

Author

Browning, Douglas F., primary, Matthews, Sophie A., additional, Rossiter, Amanda E., additional, Sevastsyanovich, Yanina R., additional, Jeeves, Mark, additional, Mason, Jessica L., additional, Wells, Timothy J., additional, Wardius, Catherine A., additional, Knowles, Timothy J., additional, Cunningham, Adam F., additional, Bavro, Vassiliy N., additional, Overduin, Michael, additional, and Henderson, Ian R., additional

Published
2013
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10. IL-4Rα-Associated Antigen Processing by B Cells Promotes Immunity in Nippostrongylus brasiliensis Infection

Author

Horsnell, William G. C., primary, Darby, Matthew G., additional, Hoving, Jennifer C., additional, Nieuwenhuizen, Natalie, additional, McSorley, Henry J., additional, Ndlovu, Hlumani, additional, Bobat, Saeeda, additional, Kimberg, Matti, additional, Kirstein, Frank, additional, Cutler, Anthony J., additional, DeWals, Benjamin, additional, Cunningham, Adam F., additional, and Brombacher, Frank, additional

Published
2013
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11. Genotypic and Phenotypic Characterisation of Enteroaggregative Escherichia coli from Children in Rio de Janeiro, Brazil

Author

França, Fernanda L. S., primary, Wells, Timothy J., additional, Browning, Douglas F., additional, Nogueira, Raquel Tayar, additional, Sarges, Felipe Silva, additional, Pereira, Ana Claudia, additional, Cunningham, Adam F., additional, Lucheze, Kely, additional, Rosa, Ana Claudia Paula, additional, Henderson, Ian R., additional, and de Luna, Maria das Graças, additional

Published
2013
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13. Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

Author

Serre, Karine, primary, Bénézech, Cécile, additional, Desanti, Guillaume, additional, Bobat, Saeeda, additional, Toellner, Kai-Michael, additional, Bird, Roger, additional, Chan, Susan, additional, Kastner, Philippe, additional, Cunningham, Adam F., additional, MacLennan, Ian C. M., additional, and Mohr, Elodie, additional

Published
2011
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14. Complete Genome Sequence and Comparative Metabolic Profiling of the Prototypical Enteroaggregative Escherichia coli Strain 042

Author

Chaudhuri, Roy R., primary, Sebaihia, Mohammed, additional, Hobman, Jon L., additional, Webber, Mark A., additional, Leyton, Denisse L., additional, Goldberg, Martin D., additional, Cunningham, Adam F., additional, Scott-Tucker, Anthony, additional, Ferguson, Paul R., additional, Thomas, Christopher M., additional, Frankel, Gad, additional, Tang, Christoph M., additional, Dudley, Edward G., additional, Roberts, Ian S., additional, Rasko, David A., additional, Pallen, Mark J., additional, Parkhill, Julian, additional, Nataro, James P., additional, Thomson, Nicholas R., additional, and Henderson, Ian R., additional

Published
2010
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