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Your search keyword '"Cathrine Juel Lau"' showing total 2 results
Start Over Author "Cathrine Juel Lau" Publisher public library of science (plos)
2 results on '"Cathrine Juel Lau"'

1. A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes.

Author

Malene Hornbak, Kristine Højgaard Allin, Majken Linnemann Jensen, Cathrine Juel Lau, Daniel Witte, Marit Eika Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Åsa Andersson, Oluf Pedersen, and Torben Hansen

Subjects
Medicine, Science
Abstract

To investigate the genetic influence of 48 type 2 diabetes susceptibility variants on disease progression measured as risk of early prescription redemption of glucose lowering drugs in screen-detected patients with type 2 diabetes.We studied type 2 diabetes progression in 1,480 patients with screen-detected type 2 diabetes from the ADDITION-Denmark study using information of redeemed prescriptions from the Register of Medicinal Products Statistics from 2001-2009 in Denmark. Patients were cluster randomized by general practitioners, who were randomized to treat type 2 diabetes according to either a conventional or a multifactorial intensive treatment algorithm. We investigated the genetic influence on diabetes progression by constructing a genetic risk score (GRS) of all 48 validated type 2 diabetes susceptibility variants, a GRS of 11 variants linked to β-cell function and a GRS of 3 variants linked to insulin sensitivity and assessed the association between number of risk alleles and time from diagnosis until first redeemed prescription of either any glucose lowering drug or an insulin drug.The GRS linked to insulin sensitivity only nominally increased the risk of an early prescription redemption with an insulin drug by 39% (HR [95% C.I.] = 1.39 [1.09-1.77], p = 0.009] in patients randomized to the intensive treatment group. Furthermore, the strongest univariate predictors of diabetes progression for the intensive treatment group (measured as time to first insulin) were younger age (HR [95% C.I.] = 0.96 [0.93-0.99]), increased BMI (1.05 [1.01-1.09]), increased HbA1c (1.50 [1.36-.66]), increased TG (1.24 [1.11-1.39]) and reduced fasting serum HDL (0.37 [0.17-0.80]) at baseline. Similar results were obtained for the conventional treatment group.Higher levels of HbA1c, fasting circulating levels of triglyceride, lower HDL, larger BMI and younger age are significant determinants of early pharmacological intervention in type 2 diabetes. However, known common type 2 diabetes-associated gene variants do not appear to significantly affect disease progression.

Published
2014
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2. Somatic Symptoms: Prevalence, Co-Occurrence and Associations with Self-Perceived Health and Limitations Due To Physical Health – A Danish Population-Based Study

Author

Jeanette Frost Ebstrup, Torben Jørgensen, Sine Skovbjerg, Chalotte Heinsvig Poulsen, Svend Kreiner, Marie Eliasen, Per Fink, and Cathrine Juel Lau

Subjects
Male, myalgia, Abdominal pain, Activities of daily living, Cross-sectional study, Denmark, Health Status, lcsh:Medicine, Otology, Pathology and Laboratory Medicine, Chest pain, Infographics, Database and Informatics Methods, 0302 clinical medicine, Surveys and Questionnaires, Activities of Daily Living, Health care, Prevalence, Medicine and Health Sciences, 030212 general & internal medicine, lcsh:Science, Visual Impairments, education.field_of_study, Multidisciplinary, Headaches, Age Factors, Middle Aged, Vertigo, Female, medicine.symptom, Graphs, Research Article, Adult, Computer and Information Sciences, medicine.medical_specialty, Population, Pain, Health Informatics, Dermatology, Rashes, Research and Analysis Methods, 03 medical and health sciences, Sex Factors, Signs and Symptoms, medicine, Humans, Pain Management, Psychiatry, education, Aged, business.industry, Data Visualization, lcsh:R, Myalgia, Abdominal Pain, Ophthalmology, Cross-Sectional Studies, Otorhinolaryngology, lcsh:Q, business, 030217 neurology & neurosurgery
Abstract

A high number of somatic symptoms have been associated with poor health status and increased health care use. Previous studies focused on number of symptoms without considering the specific symptoms. The aim of the study was to investigate 1) the prevalence of 19 somatic symptoms, 2) the associations between the symptoms, and 3) the associations between the somatic symptoms, self-perceived health and limitations due to physical health accounting for the co-occurrence of symptoms. Information on 19 somatic symptoms, self-perceived health and limitations due to physical health was achieved from a population-based questionnaire survey of 36,163 randomly selected adults in the Capital Region of Denmark in 2006/07. Chain graph models were used to transparently identify and describe the associations between symptoms, self-perceived health and limitations due to physical health. In total, 94.9% of the respondents were bothered by one or more of the 19 somatic symptoms. The symptoms were associated in a complex structure. Still, recognisable patterns were identified within organ systems/body parts. When accounting for symptom co-occurrence; dizziness, pain in legs, respiratory distress and tiredness were all strongly directly associated with both of the outcomes (γ>0.30). Chest pain was strongly associated with self-perceived health, and other musculoskeletal symptoms and urinary retention were strongly associated with limitations due to physical health. Other symptoms were either moderate or not statistically associated with the health status outcomes. Opposite, almost all the symptoms were strongly associated with the two outcomes when not accounting for symptom co-occurrence. In conclusion, we found that somatic symptoms were frequent and associated in a complex structure. The associations between symptoms and health status measures differed between the symptoms and depended on the co-occurrence of symptoms. This indicates an importance of considering both the specific symptoms and symptom co-occurrence in further symptom research instead of merely counting symptoms.

Published
2016
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