1. Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome
- Author
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Lucía Méndez, Vanessa Sánchez-Martos, Núria Taltavull, Manuel Pazos, Jara Pérez-Jiménez, Josep Lluís Torres, Sara Ramos-Romero, Marta Cascante, Laura Lluís, Eunice Molinar-Toribio, Isabel Medina, Marta Romeu, Anibal Miranda, Universitat de Barcelona, Ministerio de Economía y Competitividad (España), Ciències Mèdiques Bàsiques, and Universitat Rovira i Virgili.
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Síndrome metabòlica ,Physiology ,medicine.medical_treatment ,Adipose tissue ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Biochemistry ,Antioxidants ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Blood plasma ,Medicine and Health Sciences ,Endothelial dysfunction ,Metabolic Syndrome ,0303 health sciences ,Multidisciplinary ,Metabolic syndrome ,3. Good health ,Enzymes ,Type 2 Diabetes ,Phenotype ,Physiological Parameters ,Cardiovascular Diseases ,Medicine ,Female ,Research Article ,medicine.medical_specialty ,Estrès oxidatiu ,Science ,Cardiology ,Biology ,Infermeria cardiovascular ,03 medical and health sciences ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Animals ,Obesity ,Cardiovascular disease nursing ,030304 developmental biology ,Nutrition ,Diabetic Endocrinology ,Insulin ,Body Weight ,Biology and Life Sciences ,medicine.disease ,Rats ,Disease Models, Animal ,Oxidative Stress ,Oxidative stress ,Metabolic Disorders ,Enzymology ,Biomarkers - Abstract
8 páginas, 3 tablas.-- Eunice Molinar Toribio ... et al.-- This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited., SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions., This research was supported by the Spanish Ministries of Science and Innovation and of Economy and Competitiveness (Grants AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R; respectively) and in part by the Generalitat de Catalunya regional authorities (2009SGR-1308). M.C. acknowledges ETHERPATHS (FP7-KBBE-222639) funded by the European Union and “ICREA Academia” award for excellence in research, funded by the ICREA Foundation of the Generalitat de Catalunya. The Panamanian Government (SENACYT/IFRHU) and the Spanish Ministry of Science and Innovation awarded graduate fellowships to E.M.-T. and L.M., respectively. The ISCIII and the Xunta de Galicia are also acknowledged for “Sara Borrell” and “Isidro Parga Pondal” postdoctoral contracts to J.P.-J. (CD09/00068) and M.P., respectively.
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- 2014