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Your search keyword '"Aline Pereira da Rocha"' showing total 2 results
Start Over Author "Aline Pereira da Rocha" Publisher public library of science (plos)
2 results on '"Aline Pereira da Rocha"'

1. Hospitalization costs of coronaviruses diseases in upper-middle-income countries: A systematic review.

Author

César Ramos Rocha-Filho, Johnny Wallef Leite Martins, Rosa Camila Lucchetta, Gabriel Sodré Ramalho, Giulia Fernandes Moça Trevisani, Aline Pereira da Rocha, Ana Carolina Pereira Nunes Pinto, Felipe Sebastião de Assis Reis, Laura Jantsch Ferla, Patrícia de Carvalho Mastroianni, Luci Correa, Humberto Saconato, and Virgínia Fernandes Moça Trevisani

Subjects
Medicine, Science
Abstract

BackgroundCOVID-19, SARS and MERS are diseases that present an important health burden worldwide. This situation demands resource allocation to the healthcare system, affecting especially middle- and low-income countries. Thus, identifying the main cost drivers is relevant to optimize patient care and resource allocation.ObjectiveTo systematically identify and summarize the current status of knowledge on direct medical hospitalization costs of SARS, MERS, or COVID-19 in Upper-Middle-Income Countries.MethodsWe conducted a systematic review across seven key databases (PubMed, EMBASE, BVS Portal, CINAHL, CRD library, MedRxiv and Research Square) from database inception to February 2021. Costs extracted were converted into 2021 International Dollars using the Purchasing Power Parity-adjusted. The assessment of quality was based on the protocol by the BMJ and CHEERS. PROSPERO 2020: CRD42020225757.ResultsNo eligible study about SARS or MERS was recovered. For COVID-19, five studies presented cost analysis performed in Brazil, China, Iran, and Turkey. Regarding total direct medical costs, the lowest cost per patient at ward was observed in Turkey ($900.08), while the highest in Brazil ($5,093.38). At ICU, the lowest was in Turkey ($2,984.78), while the highest was in China ($52,432.87). Service care was the most expressive (58% to 88%) cost driver of COVID-19 patients at ward. At ICU, there was no consensus between service care (54% to 87%) and treatment (72% to 81%) as key burdens of total cost.ConclusionOur findings elucidate the importance of COVID-19 on health-economic outcomes. The marked heterogeneity among studies leaded to substantially different results and made challenging the comparison of data to estimate pooled results for single countries or regions. Further studies concerning cost estimates from standardized analysis may provide clearer data for a more substantial analysis. This may help care providers and policy makers to organize care for patients in the most efficient way.

Published
2022
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2. Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

Author

Aline Pereira da Rocha, Lilian David de Azevedo Valadares, Virginia Fernandes Moça Trevisani, Rejane Maria Rodrigues de Abreu Vieira, Gilda Aparecida Ferreira, Ana Carolina Pereira Nunes Pinto, Keilla Martins Milby, Rodolfo Rodrigo Pereira Santos, Gecilmara S. Pileggi, Viviane Angelina de Souza, Ana Luiza M. A. Caparroz, and Ana Karla G. Melo

Subjects
Viral Diseases, Physiology, 030204 cardiovascular system & hematology, Severity of Illness Index, Biochemistry, Procalcitonin, chemistry.chemical_compound, 0302 clinical medicine, Medical Conditions, Mathematical and Statistical Techniques, Immune Physiology, Leukocytes, Medicine and Health Sciences, 030212 general & internal medicine, Immune Response, Innate Immune System, Multidisciplinary, Hematology, biology, Statistics, Metaanalysis, C-Reactive Proteins, Cytokine release syndrome, C-Reactive Protein, Infectious Diseases, Meta-analysis, Creatinine, Physical Sciences, Cytokines, Medicine, Cytokine Release Syndrome, Research Article, medicine.medical_specialty, Science, Immunology, Research and Analysis Methods, 03 medical and health sciences, Signs and Symptoms, Internal medicine, Severity of illness, medicine, Humans, Statistical Methods, Inflammation, Ferritin, business.industry, Interleukin-6, SARS-CoV-2, C-reactive protein, COVID-19, Biology and Life Sciences, Proteins, Protein Complexes, Covid 19, Molecular Development, medicine.disease, chemistry, Immune System, Ferritins, biology.protein, Clinical Medicine, business, Cytokine storm, Biomarkers, Mathematics, Developmental Biology
Abstract

Objective To describe the laboratory parameters and biomarkers of the cytokine storm syndrome associated with severe and fatal COVID-19 cases. Methods A search with standardized descriptors and synonyms was performed on November 28th, 2020 of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, LILACS, and IBECS to identify studies of interest. Grey literature searches and snowballing techniques were additionally utilized to identify yet-unpublished works and related citations. Two review authors independently screened the retrieved titles and abstracts, selected eligible studies for inclusion, extracted data from the included studies, and then assessed the risk of bias using the Newcastle-Ottawa Scale. Eligible studies were those including laboratory parameters—including serum interleukin-6 levels—from mild, moderate, or severe COVID-19 cases. Laboratory parameters, such as interleukin-6, ferritin, hematology, C-Reactive Protein, procalcitonin, lactate dehydrogenase, aspartate aminotransferase, creatinine, and D-dimer, were extracted from the studies. Meta-analyses were conducted using the laboratory data to estimate mean differences with associated 95% confidence intervals. Data synthesis The database search yielded 9,620 records; 40 studies (containing a total of 9,542 patients) were included in the final analysis. Twenty-one studies (n = 4,313) assessed laboratory data related to severe COVID-19 cases, eighteen studies (n = 4,681) assessed predictors for fatal COVID-19 cases and one study (n = 548) assessed laboratory biomarkers related to severe and fatal COVID-19 cases. Lymphopenia, thrombocytopenia, and elevated levels of interleukin-6, ferritin, D-dimer, aspartate aminotransferase, C-Reactive-Protein, procalcitonin, creatinine, neutrophils and leucocytes were associated with severe and fatal COVID-19 cases. Conclusions This review points to interleukin-6, ferritin, leukocytes, neutrophils, lymphocytes, platelets, C-Reactive Protein, procalcitonin, lactate dehydrogenase, aspartate aminotransferase, creatinine, and D-dimer as important biomarkers of cytokine storm syndrome. Elevated levels of interleukin-6 and hyperferritinemia should be considered as red flags of systemic inflammation and poor prognosis in COVID-19.

Published
2021

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