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Start Over Author "Alexander Semmler" Publisher public library of science (plos)
2 results on '"Alexander Semmler"'

1. A possible genetic link between MTHFR genotype and smoking behavior.

Author

Michael Linnebank, Susanna Moskau, Alexander Semmler, Barbara Hoefgen, Gisela Bopp, Ulf Kallweit, Wolfgang Maier, Christian G Schütz, and Ullrich Wüllner

Subjects
Medicine, Science
Abstract

BACKGROUND: Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the MTHFR variants C677T and A1298C in two independent samples of 525 and 535 individuals, respectively. 21% of the non-smokers, but only 12% of the smokers were homozygous carriers of both MTHFR wildtype alleles, i.e. 677CC and 1298AA (Chi² = 15.8; p

Published
2012
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2. A possible genetic link between MTHFR genotype and smoking behavior

Author

Ulf Kallweit, Wolfgang Maier, Gisela Bopp, Michael Linnebank, Susanna Moskau, Barbara Hoefgen, Ullrich Wüllner, Christian G. Schütz, Alexander Semmler, University of Zurich, and Linnebank, M

Subjects
Male, Linkage disequilibrium, Pulmonology, Homocysteine, Epidemiology, Genetic Linkage, lcsh:Medicine, Cardiovascular, chemistry.chemical_compound, Pathology, lcsh:Science, Stroke, Genetics, Multidisciplinary, biology, Smoking, Confounding, Middle Aged, Neurology, Cardiovascular Diseases, Medicine, Female, Public Health, Research Article, Adult, medicine.medical_specialty, Hyperhomocysteinemia, Tobacco Control, Genotype, Cerebrovascular Diseases, 610 Medicine & health, 1100 General Agricultural and Biological Sciences, Polymorphism, Single Nucleotide, 1300 General Biochemistry, Genetics and Molecular Biology, Diagnostic Medicine, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Risk factor, Cardiovascular Disease Epidemiology, Methylenetetrahydrofolate Reductase (NADPH2), Clinical Genetics, 1000 Multidisciplinary, Vascular disease, business.industry, lcsh:R, Smoking Related Disorders, medicine.disease, digestive system diseases, 10040 Clinic for Neurology, Behavior, Addictive, Biomarker Epidemiology, Endocrinology, chemistry, Methylenetetrahydrofolate reductase, biology.protein, lcsh:Q, business, Biomarkers, General Pathology
Abstract

BACKGROUND: Hyperhomocysteinemia is an independent risk factor for stroke and other vascular events. The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease. However, MTHFR variants have also been reported to be associated with smoking behavior, which could be an important confounder. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed the MTHFR variants C677T and A1298C in two independent samples of 525 and 535 individuals, respectively. 21% of the non-smokers, but only 12% of the smokers were homozygous carriers of both MTHFR wildtype alleles, i.e. 677CC and 1298AA (Chi² = 15.8; p

Published
2012

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