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We sought to evaluate the adherence of Vietnamese adults to Coronavirus Disease 2019 (COVID-19) preventive measures, and gain insight into the effects of the epidemic on the daily lives of Vietnamese people. An online questionnaire was administered from March 31 to April 6, 2020. The questionnaire assessed personal preventive behavior (such as physical distancing, wearing a face mask, cough etiquette, regular handwashing and using an alcohol hand sanitizer, body temperature check, and disinfecting mobile phones) and community preventive behavior (such as avoiding meetings, large gatherings, going to the market, avoiding travel in a vehicle/bus with more than 10 persons, and not traveling outside of the local area during the lockdown). A total adherence score was calculated by summing the scores of the 9 personal and the 11 community prevention questions. In total, 2175 respondents completed the questionnaire; mean age: 31.4 ± 10.7; (range: 18–69); 66.9% were women; 54.2% were health professionals and 22.8% were medical students. The mean adherence scores for personal and community preventive measures were 7.23 ± 1.63 (range 1–9) and 9.57 ± 1.12 (range 1–11), respectively. Perceived adaptation of the community to lockdown (Beta (β) = 2.64, 95% Confidence Interval (CI) 1.25–4.03), fears/worries concerning one's health (β = 2.87, 95% CI 0.04–5.70), residing in large cities (β = 19.40, 95% CI 13.78–25.03), access to official COVID-19 information sources (β = 16.45, 95% CI 6.82–26.08), and working in healthcare/medical students (β = 22.53, 95% CI 16.00–29.07) were associated with a higher adherence score to anti-COVID instructions. In conclusion, this study confirmed a high degree of adherence to personal and community preventive behavior among Vietnamese people. Our findings are consistent with the epidemiology of COVID-19 in Vietnam, where there have been few infections and no recorded deaths up to the first week of July 2020. [ABSTRACT FROM AUTHOR]