1. Protective Effect of Ginseng Polysaccharides on Influenza Viral Infection.
- Author
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Dae-Goon Yoo, Min-Chul Kim, Min-Kyung Park, Kyoung-Mi Park, Fu-Shi Quan, Jae-Min Song, Jae Joon Wee, Bao-Zhong Wang, Young-Keol Cho, Compans, Richard W., and Sang-Moo Kang
- Subjects
GINSENG ,POLYSACCHARIDES ,VIRUS diseases ,IMMUNOREGULATION ,CYTOKINES - Abstract
Ginseng polysaccharide has been known to have multiple immunomodulatory effects. In this study, we investigated whether Panax ginseng polysaccharide (GP) would have a preventive effect on influenza infection. Administration of mice with GP prior to infection was found to confer a survival benefit against infection with H1N1 (A/PR/8/34) and H3N2 (A/ Philippines/82) influenza viruses. Mice infected with the 2009 H1N1 virus suspended in GP solution showed moderately enhanced survival rates and lower levels of lung viral titers and the inflammatory cytokine (IL-6). Daily treatment of vaccinated mice with GP improved their survival against heterosubtypic lethal challenge. This study demonstrates the first evidence that GP can be used as a remedy against influenza viral infection. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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