1. Noninvasive scoring systems predict hepatic and extra-hepatic cancers in patients with nonalcoholic fatty liver disease
- Author
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Orly Sneh Arbib, Noam Peleg, Marius Braun, Assaf Issachar, Amir Shlomai, and Michal Cohen-Naftaly
- Subjects
Liver Cirrhosis ,Male ,Physiology ,Biopsy ,lcsh:Medicine ,Nonalcoholic Steatohepatitis ,Gastroenterology ,0302 clinical medicine ,Endocrinology ,Fibrosis ,Animal Cells ,Non-alcoholic Fatty Liver Disease ,Nonalcoholic fatty liver disease ,Medicine and Health Sciences ,Medicine ,lcsh:Science ,Multidisciplinary ,medicine.diagnostic_test ,Mortality rate ,Liver Diseases ,Incidence ,Fatty liver ,Liver Neoplasms ,Middle Aged ,Type 2 Diabetes ,Body Fluids ,Survival Rate ,Blood ,030220 oncology & carcinogenesis ,Liver biopsy ,Predictive value of tests ,Liver Fibrosis ,030211 gastroenterology & hepatology ,Female ,Anatomy ,Cellular Types ,Research Article ,Platelets ,Adult ,medicine.medical_specialty ,Death Rates ,Endocrine Disorders ,Surgical and Invasive Medical Procedures ,Gastroenterology and Hepatology ,Disease-Free Survival ,03 medical and health sciences ,Population Metrics ,Predictive Value of Tests ,Internal medicine ,Diabetes Mellitus ,Humans ,Survival rate ,Aged ,Blood Cells ,Population Biology ,business.industry ,lcsh:R ,Biology and Life Sciences ,Cell Biology ,medicine.disease ,Fatty Liver ,Metabolic Disorders ,lcsh:Q ,business ,Developmental Biology ,Follow-Up Studies - Abstract
Background Liver fibrosis predicts liver-related morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD). Non-invasive scores correlate with the degree of liver fibrosis in these patients. Aims and methods To investigate the accuracy of noninvasive scoring systems in predicting long-term outcomes and cancer incidence of patients with NAFLD, we performed a single-center retrospective study of patients with biopsy proven NAFLD. Mean follow up period was 100 months. Outcomes included liver-related complications, hospitalizations, overall mortality and the development of any malignancies. Results 32 patients had advanced fibrosis (F3-F4) per biopsy at baseline and 121 patients had mild to moderate fibrosis (F0-F2). Both advanced histologic fibrosis stage as well as higher non-invasive scores predicted repeated hospitalizations and longer hospitalization stays. In a multivariate analysis, liver fibrosis (p = 0.002), FIB-4 score (p
- Published
- 2018