1. Screening for HBV, HCV, HIV and syphilis infections among bacteriologically confirmed tuberculosis prisoners: An urgent action required
- Author
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Julio Croda, Gabriela Alves Cesar, Sarlete Ferreira Basílio, Mauricio Antonio Pompilio, Sheila Araújo Teles, Ana Rita Coimbra Motta-Castro, Marco Antonio Moreira Puga, Sandra Maria do Valle Leone de Oliveira, Vivianne de Oliveira Langraf de Castro, Sabrina Moreira dos Santos Weis-Torres, Luana Silva Soares, Larissa Melo Bandeira, Tayana Serpa Ortiz Tanaka, Grazielli Rocha de Rezende, and Renata Terumi Shiguematsu Yassuda
- Subjects
Bacterial Diseases ,RNA viruses ,Male ,HBsAg ,Social Sciences ,HIV Infections ,Hepacivirus ,medicine.disease_cause ,Treponematoses ,Geographical locations ,0302 clinical medicine ,Immunodeficiency Viruses ,Medicine and Health Sciences ,Prevalence ,Mass Screening ,030212 general & internal medicine ,Pathology and laboratory medicine ,Multidisciplinary ,Hepatitis C virus ,Coinfection ,virus diseases ,Hepatitis B ,Medical microbiology ,Middle Aged ,Infectious Diseases ,Viruses ,Medicine ,Public Health ,Pathogens ,Viral hepatitis ,Brazil ,Research Article ,Neglected Tropical Diseases ,Adult ,medicine.medical_specialty ,Hepatitis B virus ,Tuberculosis ,Science ,Urology ,030231 tropical medicine ,Sexually Transmitted Diseases ,Viral diseases ,Microbiology ,03 medical and health sciences ,Hepatitis B, Chronic ,Internal medicine ,Retroviruses ,medicine ,Humans ,Syphilis ,Treponema pallidum ,Tuberculosis, Pulmonary ,Hepatitis ,Biology and life sciences ,Flaviviruses ,business.industry ,Genitourinary Infections ,Prisoners ,Lentivirus ,Organisms ,Viral pathogens ,HIV ,Mycobacterium tuberculosis ,South America ,Hepatitis C, Chronic ,medicine.disease ,Tropical Diseases ,Hepatitis viruses ,Microbial pathogens ,Cross-Sectional Studies ,Prisons ,Law and Legal Sciences ,People and places ,business ,Criminal Justice System - Abstract
Viral hepatitis, syphilis, HIV, and tuberculosis infections in prisons have been identified globally as a public health problem. Tuberculosis (TB) and viral hepatitis co-infection may increase the risk of anti-tuberculosis treatment-induced hepatotoxicity, leading to the frequent cause of discontinuation of the first-line anti-tuberculosis drugs. Therefore, the aim of this cross-sectional study was to investigate the epidemiological features of HCV, HBV, syphilis and HIV infections among bacteriologically confirmed tuberculosis prisoners in Campo Grande (MS), Central Brazil. The participants who agreed to participate (n = 279) were interviewed and tested for the presence of active or current HCV, HBV, syphilis and HIV infections. The prevalence of HCV exposure was 4.7% (13/279; 95% CI 2.2-7.1). HCV RNA was detected in 84.6% (11/13) of anti-HCV positive samples. Out of 279 participants, 19 (6.8%; 95% CI 4.4-10.4) were HIV co-infected, 1.4% (4/279, 95% CI 0.5-3.8) had chronic hepatitis B virus (HBsAg positive) and 9.3% (26/279, 95% CI 6.4-13.4) had serological marker of exposure to hepatitis B virus (total anti-HBc positive). The prevalence of lifetime syphilis infection (anti-T. pallidum positive) was 10% (28/279, 95% CI 7.0-14.2) and active syphilis (VDRL ≥ 1/8 titre) was 5% (14/279, 95% CI 2.9-8.3). The prevalence of TB/HCV co-infection among prisoners with HIV (15.8%) was higher than among HIV-non-infected prisoners (3.8%; P
- Published
- 2019