1. Antibiotic treatment duration for bloodstream infections in critically ill children—A survey of pediatric infectious diseases and critical care clinicians for clinical equipoise.
- Author
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Pong, Sandra, Fowler, Robert A., Murthy, Srinivas, Pernica, Jeffrey M., Gilfoyle, Elaine, Fontela, Patricia, Mitsakakis, Nicholas, Bowen, Asha C., Seto, Winnie, Science, Michelle, Hutchison, James S., Jouvet, Philippe, Rishu, Asgar, and Daneman, Nick
- Subjects
CRITICALLY ill children ,INTRA-abdominal infections ,VASCULAR catheters ,COMMUNICABLE diseases ,CRITICAL care medicine ,TREATMENT duration ,PEDIATRIC intensive care ,INTENSIVE care units - Abstract
Objective: To describe antibiotic treatment durations that pediatric infectious diseases (ID) and critical care clinicians usually recommend for bloodstream infections in critically ill children. Design: Anonymous, online practice survey using five common pediatric-based case scenarios of bloodstream infections. Setting: Pediatric intensive care units in Canada, Australia and New Zealand. Participants: Pediatric intensivists, nurse practitioners, ID physicians and pharmacists. Main outcome measures: Recommended treatment durations for common infectious syndromes associated with bloodstream infections and willingness to enrol patients into a trial to study treatment duration. Results: Among 136 survey respondents, most recommended at least 10 days antibiotics for bloodstream infections associated with: pneumonia (65%), skin/soft tissue (74%), urinary tract (64%) and intra-abdominal infections (drained: 90%; undrained: 99%). For central vascular catheter-associated infections without catheter removal, over 90% clinicians recommended at least 10 days antibiotics, except for infections caused by coagulase negative staphylococci (79%). Recommendations for at least 10 days antibiotics were less common with catheter removal. In multivariable linear regression analyses, lack of source control was significantly associated with longer treatment durations (+5.2 days [95% CI: 4.4–6.1 days] for intra-abdominal infections and +4.1 days [95% CI: 3.8–4.4 days] for central vascular catheter-associated infections). Most clinicians (73–95%, depending on the source of bloodstream infection) would be willing to enrol patients into a trial of shorter versus longer antibiotic treatment duration. Conclusions: The majority of clinicians currently recommend at least 10 days of antibiotics for most scenarios of bloodstream infections in critically ill children. There is practice heterogeneity in self-reported treatment duration recommendations among clinicians. Treatment durations were similar across different infectious syndromes. Under appropriate clinical conditions, most clinicians would be willing to enrol patients into a trial of shorter versus longer treatment for common syndromes associated with bloodstream infections. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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