1. Reliability of the Glasgow Antipsychotic Side-effects Scale for Clozapine Japanese version (GASS-C-J)
- Author
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Hiroyoshi Takeuchi, Fuminari Misawa, Yuya Mizuno, Hiroyuki Uchida, Masafumi Kodama, Masaru Mimura, Nobuyuki Nomura, Kohei Kitagawa, and Ryuhei So
- Subjects
Hypersalivation ,Myoclonus ,Hospitals, Psychiatric ,Male ,Research Validity ,medicine.medical_treatment ,Drug Resistance ,Glasgow Outcome Scale ,Pathology and Laboratory Medicine ,0302 clinical medicine ,Cohen's kappa ,Japan ,Surveys and Questionnaires ,Medicine and Health Sciences ,Antipsychotics ,Clozapine ,Multidisciplinary ,Depression ,Drugs ,Research Assessment ,Middle Aged ,Schizophrenia ,Anxiety ,Medicine ,Female ,medicine.symptom ,medicine.drug ,Clinical psychology ,Research Article ,Antipsychotic Agents ,Adult ,Psychometrics ,Science ,Urology ,Research and Analysis Methods ,03 medical and health sciences ,Signs and Symptoms ,Cronbach's alpha ,Blurred vision ,Adverse Reactions ,Diagnostic Medicine ,Mental Health and Psychiatry ,medicine ,Humans ,Antipsychotic ,Pharmacology ,Incontinence ,business.industry ,Mood Disorders ,Psychoses ,Reproducibility of Results ,medicine.disease ,030227 psychiatry ,Cross-Sectional Studies ,business ,030217 neurology & neurosurgery - Abstract
The purpose of this study was to develop the Glasgow Antipsychotic Side effects Scale for Clozapine Japanese version (GASS-C-J) and examine its reliability to assess clozapine-related side effects. We developed the GASS-C-J using forward and backward translation. Semantic equivalence of the GASS-C-J to the GASS-C was confirmed by the original author. We then administered the GASS-C-J twice to 109 patients on clozapine treatment at two psychiatric hospitals in Japan. We assessed the internal consistency and test-retest reliability of the GASS-C-J using Cronbach's alpha and weighted kappa coefficient, respectively. We also examined if discrepancies in each GASS-C-J item score between the first and second rating were correlated with items of the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). The Cronbach's alpha coefficient of the GASS-C-J at the first and second rating was 0.78 (95% CI: 0.72 to 0.84) and 0.82 (95% CI: 0.76 to 0.88), respectively. The weighted kappa coefficient of individual and total GASS-C-J item scores ranged from 0.45 to 0.88. Some symptom domains were correlated with discrepancies in specific items of the GASS-C-J: psychotic symptoms and nausea/vomiting (rs = 0.27), thirst (rs = 0.31), and appetite/weight gain (rs = 0.27); disorganized thinking and urinary incontinence (rs = 0.26); depression/anxiety and myoclonus (rs = 0.25), hypersalivation (rs = -0.27), and blurred vision (rs = -0.22). These findings demonstrate that the GASS-C-J can be used in clinical and research settings as a reliable scale to assess clozapine-related side effects.
- Published
- 2020