1. Systematic screening for advanced liver fibrosis in patients with coronary artery disease: The CORONASH study.
- Author
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Thévenot, Thierry, Vendeville, Sophie, Weil, Delphine, Akkouche, Linda, Calame, Paul, Canivet, Clémence M., Vanlemmens, Claire, Richou, Carine, Cervoni, Jean-Paul, Seronde, Marie-France, Di Martino, Vincent, and Boursier, Jérôme
- Subjects
HEPATIC fibrosis ,CORONARY artery disease ,NON-alcoholic fatty liver disease ,MEDICAL screening ,DISEASE risk factors - Abstract
Although coronary artery disease (CAD) and advanced liver fibrosis (AdLF) are commonly associated in patients with non-alcoholic fatty liver disease (NAFLD), the prevalence of AdLF and the diagnostic performance of non-invasive fibrosis tests (NITs) in CAD patients remains unknown. We aimed to prospectively screen for AdLF in patients with documented CAD using NITs and Fibroscan. High and intermediate zones of NITs were combined to define AdLF. AdLF was suspected whenever APRI ≥ 0.5, Forns index ≥ 4.2, NAFLD fibrosis score (NFS) ≥ -1.455/0.12 for age 2), AdLF ranged between 10% (APRI) to 84% (Forns). In this subgroup, the most efficient NITs to predict Fibroscan ≥ 8 kPa were eLIFT (Se 60%, Sp 70%) and NFS (Se 70%, Sp 60%). Finally, in CAD patients with risk factors for NAFLD, NFS or the more user-friendly eLIFT are the most attractive first-line biochemical NITs to discriminate good candidates for Fibroscan. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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