1. Resting state networks of the canine brain under sevoflurane anaesthesia
- Author
-
Adriano Wang-Leandro, Katrin Beckmann, Aline R Steiner, Sven Haller, Inés Carrera, Matthias Dennler, Henning Richter, Rima N Bektas, University of Zurich, Chen, Xi, and Beckmann, Katrin M
- Subjects
0301 basic medicine ,Male ,Canine brain ,10253 Department of Small Animals ,Vision ,General Anesthesia ,Social Sciences ,Somatosensory system ,Diagnostic Radiology ,0302 clinical medicine ,Anesthesiology ,Functional Magnetic Resonance Imaging ,Medicine and Health Sciences ,Image Processing, Computer-Assisted ,Psychology ,Anesthesia ,Default mode network ,Mammals ,Brain Mapping ,Multidisciplinary ,medicine.diagnostic_test ,Pharmaceutics ,Radiology and Imaging ,Eukaryota ,Brain ,General Medicine ,Magnetic Resonance Imaging ,Veterinary Diseases ,Neurology ,Vertebrates ,Anesthetics, Inhalation ,11404 Department of Clinical Diagnostics and Services ,Medicine ,Sensory Perception ,Female ,General Agricultural and Biological Sciences ,Neurovetenskaper ,medicine.drug ,Radiology, Nuclear Medicine and Medical Imaging ,Research Article ,Computer and Information Sciences ,Steady state (electronics) ,Neural Networks ,Imaging Techniques ,Science ,Brain/diagnostic imaging/physiology ,Sensory system ,610 Medicine & health ,Genetics and Molecular Biology ,Neuroimaging ,1100 General Agricultural and Biological Sciences ,Research and Analysis Methods ,ddc:616.0757 ,Sevoflurane ,03 medical and health sciences ,Dogs ,Drug Therapy ,1300 General Biochemistry, Genetics and Molecular Biology ,Diagnostic Medicine ,medicine ,Animals ,Humans ,1000 Multidisciplinary ,Epilepsy ,Resting state fMRI ,business.industry ,Neurosciences ,Organisms ,Biology and Life Sciences ,Sevoflurane/administration & dosage ,Anesthetics, Inhalation/administration & dosage ,030104 developmental biology ,General Biochemistry ,Amniotes ,Veterinary Science ,Radiologi och bildbehandling ,Functional magnetic resonance imaging ,business ,030217 neurology & neurosurgery ,Neuroscience - Abstract
Resting-state functional Magnetic Resonance Imaging (rs-fMRI) has become an established technique in humans and reliably determines several resting state networks (RSNs) simultaneously. Limited data exist about RSN in dogs. The aim of this study was to investigate the RSNs in 10 healthy beagle dogs using a 3 tesla MRI scanner and subsequently perform group-level independent component analysis (ICA) to identify functionally connected brain networks. Rs-fMRI sequences were performed under steady state sevoflurane inhalation anaesthesia. Anaesthetic depth was titrated to the minimum level needed for immobilisation and mechanical ventilation of the patient. This required a sevoflurane MAC between 0.8 to 1.2. Group-level ICA dimensionality of 20 components revealed distributed sensory, motor and higher-order networks in the dogs’ brain. We identified in total 7 RSNs (default mode, primary and higher order visual, auditory, two putative motor-somatosensory and one putative somatosensory), which are common to other mammals including humans. Identified RSN are remarkably similar to those identified in awake dogs. This study proves the feasibility of rs-fMRI in anesthetized dogs and describes several RSNs, which may set the basis for investigating pathophysiological characteristics of various canine brain diseases.
- Published
- 2020