1. Vitamin D.sub.3 supplementation during pregnancy and lactation for women living with HIV in Tanzania: A randomized controlled trial
- Author
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Sudfeld, Christopher R., Manji, Karim P., Muhihi, Alfa, Duggan, Christopher P., Aboud, Said, Alwy Al-Beity, Fadhlun M., Wang, Molin, Zhang, Ning, Ulenga, Nzovu, and Fawzi, Wafaie W.
- Subjects
Maternal-fetal exchange ,Alfacalcidol -- Dosage and administration ,Calcifediol -- Dosage and administration ,Vitamin D -- Dosage and administration ,Highly active antiretroviral therapy -- Dosage and administration ,Lactation -- Health aspects ,Pregnant women -- Care and treatment ,Pediatric research ,HIV infection -- Demographic aspects -- Prevention -- Risk factors ,Biological sciences - Abstract
Background Observational studies suggest that vitamin D deficiency among people living with HIV is associated with a greater risk of disease progression and death. Low levels of vitamin D in pregnancy are also associated with poor fetal and infant growth. Therefore, vitamin D supplementation may improve clinical outcomes for pregnant women living with HIV and improve fetal and postnatal growth for their infants. Methods and findings We conducted a randomized, triple-blind, placebo-controlled trial of vitamin D.sub.3 supplementation among pregnant and lactating women living with HIV in Dar es Salaam, Tanzania (ClinicalTrials.gov NCT02305927). Participants were randomized with 1:1 allocation stratified by study clinic to receive either daily 3,000 IU vitamin D.sub.3 supplements or matching placebo supplements from the second trimester of pregnancy (12-27 weeks) until 1 year postpartum. The primary outcomes were (i) maternal HIV progression or death, (ii) small-for-gestational-age (SGA) live births ( Conclusions The trial findings do not support routine vitamin D supplementation for pregnant and lactating women living with HIV in Tanzania. Trial registration ClinicalTrials.gov Identifier: NCT02305927., Author(s): Christopher R. Sudfeld 1,2,*, Karim P. Manji 3, Alfa Muhihi 4, Christopher P. Duggan 2,5, Said Aboud 6, Fadhlun M. Alwy Al-Beity 7, Molin Wang 8,9,10, Ning Zhang 9, [...]
- Published
- 2022
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