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Introduction: Polygamy has declined in the last decade, but it is still prevalent in West African nations including Ghana even with the arrival of Christianity and colonists, which came to be recognized as a form of slavery that needed to be abolished. Aim: To analyze the determinants of polygyny among married Christian women in Ghana. Methods: Ghana Maternal Health Survey data was used for this study to do an analytic cross-section study. Data analysis was done using SPSS version 20. The association between dependent and independent variables was explored using chi-square and logistic regression. Statistical significance was set at p < 0.05. Results: The prevalence of Ghanaian Christian women's involvement in polygyny marriage union was 12.2%, the prevalence was higher (15.0%) among women of Anglican denomination, catholic denomination (13.9%), and the lowest (8.4%) prevalence recorded among those of Methodist denominations. The predictor factors identified include the age of the woman, history of education, type of place of residence, region, ethnicity, early sex initiation, and history of multiple unions. Conclusion: The prevalence of polygyny in this present study is high given the strict position the Christian religion has against polygyny. This study recommends that the pros and cons of polygyny are objectively looked at from a scientific point rather than a religious point of view. [ABSTRACT FROM AUTHOR]