1. Value of Computerized 3D Shape Analysis in Differentiating Encapsulated from Invasive Thymomas.
- Author
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Lee, Jong Hyuk, Park, Chang Min, Park, Sang Joon, Bae, Jae Seok, Lee, Sang Min, and Goo, Jin Mo
- Subjects
THYMOMA ,CANCER invasiveness ,COMPUTED tomography ,THREE-dimensional imaging ,EPITHELIAL tumors - Abstract
Objectives: To retrospectively investigate the added value of quantitative 3D shape analysis in differentiating encapsulated from invasive thymomas. Materials and Methods: From February 2002 to October 2013, 53 patients (25 men and 28 women; mean age, 53.94 ± 13.13 years) with 53 pathologically-confirmed thymomas underwent preoperative chest CT scans (slice thicknesses ≤ 2.5 mm). Twenty-three tumors were encapsulated thymomas and 30 were invasive thymomas. Their clinical and CT characteristics were evaluated. In addition, each thymoma was manually-segmented from surrounding structures, and their 3D shape features were assessed using an in-house developed software program. To evaluate the added value of 3D shape features in differentiating encapsulated from invasive thymomas, logistic regression analysis and receiver-operating characteristics curve (ROC) analysis were performed. Results: Significant differences were observed between encapsulated and invasive thymomas, in terms of cystic changes (p=0.004), sphericity (p=0.016), and discrete compactness (p=0.001). Subsequent binary logistic regression analysis revealed that absence of cystic change (adjusted odds ratio (OR) = 6.636; p=0.015) and higher discrete compactness (OR = 77.775; p=0.012) were significant differentiators of encapsulated from invasive thymomas. ROC analyses revealed that the addition of 3D shape analysis to clinical and CT features (AUC, 0.955; 95% CI, 0.935–0.975) provided significantly higher performance in differentiating encapsulated from invasive thymomas than clinical and CT features (AUC, 0.666; 95% CI, 0.626–0.707) (p<0.001). Conclusion: Addition of 3D shape analysis, particularly discrete compactness, can improve differentiation of encapsulated thymomas from invasive thymomas. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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