1. MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis
- Author
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Liangren Liu, Zhufeng Peng, Shang-Qing Ren, Bo Yang, Jian Liao, Kun Fang, Peng-Wei Ren, Zheng-Ju Ren, Sheng-Zhuo Liu, and Qiang Dong
- Subjects
0301 basic medicine ,Oncology ,Male ,Databases, Factual ,Enzyme Metabolism ,lcsh:Medicine ,Biochemistry ,5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase ,Male infertility ,Geographical Locations ,Database and Informatics Methods ,Mathematical and Statistical Techniques ,Methionine ,Risk Factors ,Medicine and Health Sciences ,Odds Ratio ,Ethnicities ,Database Searching ,Amino Acids ,lcsh:Science ,Enzyme Chemistry ,education.field_of_study ,Multidisciplinary ,biology ,Organic Compounds ,Chinese people ,Chemistry ,Meta-analysis ,Physical Sciences ,Statistics (Mathematics) ,Research Article ,Infertility ,medicine.medical_specialty ,China ,Asia ,Genotype ,Urology ,Population ,Single-nucleotide polymorphism ,Research and Analysis Methods ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Internal medicine ,medicine ,Genetics ,Male Infertility ,Sulfur Containing Amino Acids ,Humans ,Genetic Predisposition to Disease ,Statistical Methods ,education ,Alleles ,Infertility, Male ,Methylenetetrahydrofolate Reductase (NADPH2) ,Evolutionary Biology ,Population Biology ,business.industry ,lcsh:R ,Organic Chemistry ,Chemical Compounds ,Biology and Life Sciences ,Proteins ,Odds ratio ,medicine.disease ,030104 developmental biology ,Methylenetetrahydrofolate reductase ,People and Places ,biology.protein ,Enzymology ,Genetic Polymorphism ,lcsh:Q ,Population Groupings ,business ,Chinese People ,Mathematics ,Population Genetics ,Meta-Analysis - Abstract
Background Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations. Although several studies have evaluated these associations in Chinese populations, their small sample sizes and inconsistent outcomes have prevented strong conclusions. Therefore, the present meta-analysis was performed with published studies to evaluate the associations of the three single nucleotide polymorphisms (SNPs) and male infertility in a Chinese population. Methods We conducted a search of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), China biology medical literature (CBM), VIP, and Chinese literature (Wan Fang) databases up to May 31, 2016. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were used to assess the strength of associations with a random-effect model or a fixed-effect model based on the heterogeneity analysis results. Sensitivity analysis was used to confirm the reliability and stability of the meta-analysis. Results A total of nine studies, including 1,713 cases and 1,104 controls, were included in the meta-analysis. The pooled results indicated that the MTHFR C667T polymorphism was significantly associated with increased risk of male infertility in the Chinese population in the allele model (T vs. C: OR = 1.47, 95%CI = 1.32–1.63), the dominant model (TT + CT vs. CC: OR = 1.51, 95%CI = 1.30–1.77), the additive model (TT vs. CC: OR = 2.08, 95%CI = 1.68–2.58) and the recessive model (TT vs. CT+CC: OR = 1.58, 95%CI = 1.31–1.90), whereas the MTHFR A1298C and MS A2756G polymorphisms were not risk factors. There was no significant heterogeneity in any genotype contrasts among the studies. The sensitivity analysis indicated that the results of this meta-analysis were relatively stable. Conclusion This study suggests that the MTHFR C667T polymorphism may contribute to the genetic susceptibility to male infertility in the Chinese population, whereas MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results.
- Published
- 2017