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Your search keyword '"B. Jalachandra Reddy"' showing total 2 results
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2 results on '"B. Jalachandra Reddy"'

1. Development of a RP-HPLC method for evaluation of in vitro permeability of voriconazole in the presence of enhancers through rat skin

Author

G. Madhavi, Rajendra N. Dash, P. Venugopal, M. Vamsi Krishna, B. Jalachandra Reddy, and P. Sandeep

Subjects
0301 basic medicine, Voriconazole, Detection limit, Chromatography, Chemistry(all), Chemistry, 030106 microbiology, 010401 analytical chemistry, Skin diffusate samples, General Chemistry, Permeation, Permeability coefficient, 01 natural sciences, In vitro, 0104 chemical sciences, 03 medical and health sciences, Permeability (electromagnetism), RP-HPLC, medicine, Permeation enhancers, medicine.drug
Abstract

An isocratic RP-HPLC–UV method for the analysis of voriconazole in skin diffusate samples has been developed and validated. Experimental design was employed to optimize the method. The method was validated as per ICH guidelines. Linearity was observed over the concentration range of 2–100 μg mL−1 (r2 = 0.999). Limits of detection and quantification were 0.6 and 2 μg mL−1, respectively. Intra-day and inter-day precision (% RSD) was within the ICH limits (⩽2%). The method was successfully used to analyze skin diffusate samples, and the effectiveness of different permeation enhancers was compared with respect to flux and permeability coefficient.

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2. Quality by Design (QbD) approach to develop HPLC method for eberconazole nitrate: Application oxidative and photolytic degradation kinetics

Author

M. Vamsi Krishna, B. Jalachandra Reddy, P. Venugopal, P. Sandeep, G. Madhavi, and Rajendra N. Dash

Subjects
Chromatography, Chemistry(all), 010405 organic chemistry, Chemistry, 010401 analytical chemistry, Kinetics, Degradation kinetics, General Chemistry, Oxidative phosphorylation, 01 natural sciences, Quality by Design, 0104 chemical sciences, lcsh:Chemistry, Hydrolysis, chemistry.chemical_compound, Reaction rate constant, Eberconazole nitrate, lcsh:QD1-999, Nitrate, QbD approach, Degradation (geology), Stability indicating HPLC, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), ComputingMilieux_MISCELLANEOUS, Eberconazole
Abstract

Stability of eberconazole nitrate (EBZ) was investigated using a stability indicating HPLC method. Quality by Design (QbD) approach was used to facilitate method development. EBZ was exposed to different stress conditions, including hydrolytic (acid, base, neutral), oxidative, thermal and photolytic. Relevant degradation was found to take place in all the conditions. The degradation of EBZ followed (pseudo) first-order kinetics under experimental conditions. The kinetic parameters (rate constant, t1/2, and t90) of the degradation of EBZ were calculated.

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