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AIM:To investigate triple channel double ring guided treatment of lacrimal obstruction and its clinical therapeutic effect. METHODS: Fifty cases(54 eyes)of lacrimal obstruction were treated by laser or micro-drill under triple channel lacrimal endoscope with double ring guided intubation created by our department. The silicone tube was extracted at 3～6mo of postoperation. All cases were followed up 3～6mo. RESULTS:Of total 54 eyes, 47 eyes were cured, and lacrimal passage was clearly flushed without epiphora; 5 eyes were improved, but lacrimal passage was clearly flushed with slight epiphora; 2 eyes were recurred, and lacrimal passage was not clearly flushed with epiphora. Total effective rate was 96%. CONCLUSION:Triple channel double ring guided treatment of lacrimal obstruction has greatly improved traditional operation. It has dramatically increased success rate of lacrimal obstruction operation with little invasion, avoiding formation of false lacrimal passage, quick recovery and less complications.