1. Tra2 protein biology and mechanisms of splicing control
- Author
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Andrew Best, Alison Tyson-Capper, Caroline Dalgliesh, Mahsa Kheirollahi-Kouhestani, Ingrid Ehrmann, Marina Danilenko, and David J. Elliott
- Subjects
Genetics ,Brain development ,RNA recognition motif ,Arginine ,Alternative splicing ,RNA-Binding Proteins ,Computational biology ,Biology ,Biochemistry ,Serine ,Alternative Splicing ,Ribonucleoproteins ,RNA splicing ,Animals ,Drosophila Proteins ,Drosophila - Abstract
Tra2 proteins regulate pre-mRNA splicing in vertebrates and invertebrates, and are involved in important processes ranging from brain development in mice to sex determination in fruitflies. In structure Tra2 proteins contain two RS domains (domains enriched in arginine and serine residues) flanking a central RRM (RNA recognition motif). Understanding the mechanisms of how Tra2 proteins work to control splicing is one of the key requirements to understand their biology. In the present article, we review what is known about how Tra2 proteins regulate splicing decisions in mammals and fruitflies.
- Published
- 2014